Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?

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	Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?
其他题名	Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
	Ge Jing 1; Wang Jun 1; Xue Dan 1; Zhu Zhengsheng 2; Chen Zhenyu 1; Li Xiaoqiu 1; Su Dongfeng 1; Du Juan 1
	2013
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	8 期号:20 页码:1872-1880
摘要	Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hypertension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased expression of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
其他摘要	Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
关键词	PHOSPHOLIPASE A(2) OXIDATIVE STRESS ISCHEMIC-STROKE ACIDS RISK COMPLICATIONS TRIGLYCERIDES METABOLISM DISEASE WOMEN neural regeneration preeclampsia eclampsia excitatory neurotransmitter neurotoxicity hyperlipidemia hypertension pregnancy lipoprotein-associated phospholipase A2 metabotropic glutamate receptor 1 grants-supported paper neuroregeneration
收录类别	CSCD
语种	英语
资助项目	[Military Medical Science and Technology General Project]
CSCD记录号	CSCD:4902803
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/155011
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Dantu Dist Sanit Supervis Institute, Zhenjiang 212001, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Ge Jing,Wang Jun,Xue Dan,et al. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?[J]. NEURAL REGENERATION RESEARCH,2013,8(20):1872-1880.
APA	Ge Jing.,Wang Jun.,Xue Dan.,Zhu Zhengsheng.,Chen Zhenyu.,...&Du Juan.(2013).Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?.NEURAL REGENERATION RESEARCH,8(20),1872-1880.
MLA	Ge Jing,et al."Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?".NEURAL REGENERATION RESEARCH 8.20(2013):1872-1880.