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Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
Alternative TitleChanges in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
Zhao Shuai; Guo Yingying; Ding Ning; Yang Lili; Zhang Ning
2011
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume124Issue:19Pages:3058-3060
AbstractBackground Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis.
Other AbstractBackground Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients. Results The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity. Conclusion sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
KeywordCELLS rheumatoid arthritis osteoclast-associated receptor osteoclast
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4321541
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/155582
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao Shuai,Guo Yingying,Ding Ning,et al. Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3058-3060.
APA Zhao Shuai,Guo Yingying,Ding Ning,Yang Lili,&Zhang Ning.(2011).Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis.CHINESE MEDICAL JOURNAL,124(19),3058-3060.
MLA Zhao Shuai,et al."Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis".CHINESE MEDICAL JOURNAL 124.19(2011):3058-3060.
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