Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis

IMR OpenIR

	Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
其他题名	Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
	Zhao Shuai; Guo Yingying; Ding Ning; Yang Lili; Zhang Ning
	2011
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	124 期号:19 页码:3058-3060
摘要	Background Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis.
其他摘要	Background Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients. Results The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity. Conclusion sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
关键词	CELLS rheumatoid arthritis osteoclast-associated receptor osteoclast
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4321541
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/155582
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhao Shuai,Guo Yingying,Ding Ning,et al. Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3058-3060.
APA	Zhao Shuai,Guo Yingying,Ding Ning,Yang Lili,&Zhang Ning.(2011).Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis.CHINESE MEDICAL JOURNAL,124(19),3058-3060.
MLA	Zhao Shuai,et al."Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis".CHINESE MEDICAL JOURNAL 124.19(2011):3058-3060.