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Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5
Alternative TitleSynthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2 H)-ones as inhibitors of ALK5
Li Xing Zhou1; Dai Xian Ping2; Lai Kang Ying2; Wang Li Li1; Zheng Zhi Bing1; Li Song1
2008
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume19Issue:4Pages:379-382
AbstractA series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones, as ALK5 inhibitors, were desigened, synthesized and evaluated in vitro. Most compounds exhibited noticeable ALK5 inhibition activities at 1 mu mol/L and displayed no significant cytotoxicities at 30 mu mol/L. (c) 2008 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1 μmol/L and displayed no significant cytotoxicities at 30 μmol/L.
KeywordBETA IDENTIFICATION KINASE activin-like kinases5 (ALK5) kinase inhibitors 1H-pyrazol-3(2H)-ones
Indexed ByCSCD
Language英语
CSCD IDCSCD:3316681
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/155600
Collection中国科学院金属研究所
Affiliation1.Beijing Institute Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,et al. Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5[J]. CHINESE CHEMICAL LETTERS,2008,19(4):379-382.
APA Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,Wang Li Li,Zheng Zhi Bing,&Li Song.(2008).Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5.CHINESE CHEMICAL LETTERS,19(4),379-382.
MLA Li Xing Zhou,et al."Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5".CHINESE CHEMICAL LETTERS 19.4(2008):379-382.
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