Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5

IMR OpenIR

	Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5
其他题名	Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2 H)-ones as inhibitors of ALK5
	Li Xing Zhou 1; Dai Xian Ping 2; Lai Kang Ying 2; Wang Li Li 1; Zheng Zhi Bing 1; Li Song 1
	2008
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	19 期号:4 页码:379-382
摘要	A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones, as ALK5 inhibitors, were desigened, synthesized and evaluated in vitro. Most compounds exhibited noticeable ALK5 inhibition activities at 1 mu mol/L and displayed no significant cytotoxicities at 30 mu mol/L. (c) 2008 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1 μmol/L and displayed no significant cytotoxicities at 30 μmol/L.
关键词	BETA IDENTIFICATION KINASE activin-like kinases5 (ALK5) kinase inhibitors 1H-pyrazol-3(2H)-ones
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3316681
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/155600
专题	中国科学院金属研究所
作者单位	1.Beijing Institute Pharmacol & Toxicol, Beijing 100850, Peoples R China 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,et al. Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5[J]. CHINESE CHEMICAL LETTERS,2008,19(4):379-382.
APA	Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,Wang Li Li,Zheng Zhi Bing,&Li Song.(2008).Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5.CHINESE CHEMICAL LETTERS,19(4),379-382.
MLA	Li Xing Zhou,et al."Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5".CHINESE CHEMICAL LETTERS 19.4(2008):379-382.