Growth of Dynamic Actin Filament via Brownian Dynamics Simulations

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	Growth of Dynamic Actin Filament via Brownian Dynamics Simulations
其他题名	Growth of Dynamic Actin Filament via Brownian Dynamics Simulations
	Guo Kunkun 1; Han Wenchi 2
	2011
发表期刊	ACTA CHIMICA SINICA
ISSN	0567-7351
卷号	69 期号:2 页码:145-152
摘要	Actin polymerization is coupled with the hydrolysis of adenosine triphosphate (ATP). The hydrolysates of ATP are adenosine diphosphate (ADP) and inorganic phosphate (Pi). Therefore, each protomer within the actin filament can exhibit three different nucleotide states corresponding to bounded ATP, ADP/Pi and ADP molecules. These protomer states cause the filaments to form different spatial patterns, which will change various properties of the filament. The related model has been made to simulate the process of polymerization, depolymerization and hydrolysis via Brownian dynamics simulations, where the time evolution of depolymerization and hydrolysis is described as a continuous-time Markov process. In this paper, we focus on how to realize the chemical equilibrium between two ends of the filament, and study the growth behavior of long filaments as a function of ATP-actin monomer concentration.
关键词	POLYMERIZATION KINETICS SYMMETRY-BREAKING MOTILITY DRIVEN CELL MOTILITY ADP-ACTIN MODEL TURNOVER brownian dynamics actin filament polymerization depolymerization
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4133426
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156003
专题	中国科学院金属研究所
作者单位	1.湖南大学 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Guo Kunkun,Han Wenchi. Growth of Dynamic Actin Filament via Brownian Dynamics Simulations[J]. ACTA CHIMICA SINICA,2011,69(2):145-152.
APA	Guo Kunkun,&Han Wenchi.(2011).Growth of Dynamic Actin Filament via Brownian Dynamics Simulations.ACTA CHIMICA SINICA,69(2),145-152.
MLA	Guo Kunkun,et al."Growth of Dynamic Actin Filament via Brownian Dynamics Simulations".ACTA CHIMICA SINICA 69.2(2011):145-152.