IMR OpenIR
Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers
Alternative TitlePharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers
Zhao Longshan1; Guo Tao2; Xia Dongya2
2010
Source Publication中国新药与临床杂志
ISSN1007-7669
Volume000Issue:011Pages:822-826
AbstractAIM To study the pharmacokinetics of modafinil tablets in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality.METHODS Thirty healthy Chinese Mongolian,Uygur and Hui volunteers(10 for every nationality,half males,half females) were given modafinil 200 mg,and the plasma samples were collected and determined by HPLC-UV method.The main pharmacokinetic parameters of modafinil and its metabolite modafinil acid in the three nationalities and different sexes were calculated with the DAS 2.0 practical pharmacokinetic program.RESULTS After a single oral dose of modafinil 200 mg,the main pharmacokinetic parameters of modafinil for Mongolian,Uygur and Hui nationality were as follows: t1/2(13 ± s 3),(15 ± 4),and(14 ± 2) h;tmax(2.2 ± 0.8),(1.8 ± 0.5),and(1.9 ± 0.9) h;ρmax(4.9 ± 0.7),(4.8 ± 0.7),and(4.7 ± 1.0) mg.L-1;AUC0-∞(69 ± 12),(71 ± 16),and(71 ± 20) mg.h.L-1,while the pharmacokinetic parameters of modafinil acid of the above three nationalities were: t1/2(5.2 ± 1.2),(7.2 ± 0.7),and(7.1 ± 1.8) h;tmax(2.9 ± 0.9),(3.1 ± 1.3),and(2.9 ± 1.1) h;ρmax(3.5 ± 0.8),(2.8 ± 0.4),and (2.8 ± 0.5) mg.L-1;AUC0-∞(34 ± 8),(34 ± 6),and(34 ± 4) mg.h.L-1.There were no significant differences observed(P 0.05) among the pharmacokinetic parameters between the three nationalities.Meanwhile,the pharmacokinetic parameters calculated according sex showed that the values ρmax(male(4.3 ± 0.5) vs.female(5.3 ± 0.7) mg.L-1,P 0.01) and Vd(male(65 ± 10) vs.female(51 ± 8) L,P 0.01)for modafinil and tmax(male(2.5 ± 0.9) vs.female(3.4 ± 1.1) h,P 0.05) and ρmax(male(2.8 ± 0.5) vs.female(3.3 ± 0.7) mg.L-1,P 0.05) for modafinil acid exhibited statistically significant differences.CONCLUSION Nationality has no significant impact on the pharmacokinetic parameters in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality after a single dose of modafinil tablets.However,there is some pharmacokinetic differences related to sex,which suggests possible requirements of dosage adjustments for sex difference.
Other AbstractAIM To study the pharmacokinetics of modafinil tablets in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality.METHODS Thirty healthy Chinese Mongolian,Uygur and Hui volunteers(10 for every nationality,half males,half females) were given modafinil 200 mg,and the plasma samples were collected and determined by HPLC-UV method.The main pharmacokinetic parameters of modafinil and its metabolite modafinil acid in the three nationalities and different sexes were calculated with the DAS 2.0 practical pharmacokinetic program.RESULTS After a single oral dose of modafinil 200 mg,the main pharmacokinetic parameters of modafinil for Mongolian,Uygur and Hui nationality were as follows: t1/2(13 ± s 3),(15 ± 4),and(14 ± 2) h;tmax(2.2 ± 0.8),(1.8 ± 0.5),and(1.9 ± 0.9) h;ρmax(4.9 ± 0.7),(4.8 ± 0.7),and(4.7 ± 1.0) mg.L-1;AUC0-∞(69 ± 12),(71 ± 16),and(71 ± 20) mg.h.L-1,while the pharmacokinetic parameters of modafinil acid of the above three nationalities were: t1/2(5.2 ± 1.2),(7.2 ± 0.7),and(7.1 ± 1.8) h;tmax(2.9 ± 0.9),(3.1 ± 1.3),and(2.9 ± 1.1) h;ρmax(3.5 ± 0.8),(2.8 ± 0.4),and (2.8 ± 0.5) mg.L-1;AUC0-∞(34 ± 8),(34 ± 6),and(34 ± 4) mg.h.L-1.There were no significant differences observed(P 0.05) among the pharmacokinetic parameters between the three nationalities.Meanwhile,the pharmacokinetic parameters calculated according sex showed that the values ρmax(male(4.3 ± 0.5) vs.female(5.3 ± 0.7) mg.L-1,P 0.01) and Vd(male(65 ± 10) vs.female(51 ± 8) L,P 0.01)for modafinil and tmax(male(2.5 ± 0.9) vs.female(3.4 ± 1.1) h,P 0.05) and ρmax(male(2.8 ± 0.5) vs.female(3.3 ± 0.7) mg.L-1,P 0.05) for modafinil acid exhibited statistically significant differences.CONCLUSION Nationality has no significant impact on the pharmacokinetic parameters in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality after a single dose of modafinil tablets.However,there is some pharmacokinetic differences related to sex,which suggests possible requirements of dosage adjustments for sex difference.
Keyword莫达非尼 蒙古族 维吾尔族 回族 药动学 色谱法 高压液相
Indexed ByCSCD
Language中文
CSCD IDCSCD:4085846
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/156190
Collection中国科学院金属研究所
Affiliation1.沈阳药科大学
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao Longshan,Guo Tao,Xia Dongya. Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers[J]. 中国新药与临床杂志,2010,000(011):822-826.
APA Zhao Longshan,Guo Tao,&Xia Dongya.(2010).Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers.中国新药与临床杂志,000(011),822-826.
MLA Zhao Longshan,et al."Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers".中国新药与临床杂志 000.011(2010):822-826.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao Longshan]'s Articles
[Guo Tao]'s Articles
[Xia Dongya]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao Longshan]'s Articles
[Guo Tao]'s Articles
[Xia Dongya]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao Longshan]'s Articles
[Guo Tao]'s Articles
[Xia Dongya]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.