Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers

IMR OpenIR

	Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers
其他题名	Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers
	Zhao Longshan 1; Guo Tao 2; Xia Dongya 2
	2010
发表期刊	中国新药与临床杂志
ISSN	1007-7669
卷号	000 期号:011 页码:822-826
摘要	AIM To study the pharmacokinetics of modafinil tablets in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality.METHODS Thirty healthy Chinese Mongolian,Uygur and Hui volunteers（10 for every nationality,half males,half females） were given modafinil 200 mg,and the plasma samples were collected and determined by HPLC-UV method.The main pharmacokinetic parameters of modafinil and its metabolite modafinil acid in the three nationalities and different sexes were calculated with the DAS 2.0 practical pharmacokinetic program.RESULTS After a single oral dose of modafinil 200 mg,the main pharmacokinetic parameters of modafinil for Mongolian,Uygur and Hui nationality were as follows： t1/2（13 ± s 3）,（15 ± 4）,and（14 ± 2） h;tmax（2.2 ± 0.8）,（1.8 ± 0.5）,and（1.9 ± 0.9） h;ρmax（4.9 ± 0.7）,（4.8 ± 0.7）,and（4.7 ± 1.0） mg.L-1;AUC0-∞（69 ± 12）,（71 ± 16）,and（71 ± 20） mg.h.L-1,while the pharmacokinetic parameters of modafinil acid of the above three nationalities were： t1/2（5.2 ± 1.2）,（7.2 ± 0.7）,and（7.1 ± 1.8） h;tmax（2.9 ± 0.9）,（3.1 ± 1.3）,and（2.9 ± 1.1） h;ρmax（3.5 ± 0.8）,（2.8 ± 0.4）,and （2.8 ± 0.5） mg.L-1;AUC0-∞（34 ± 8）,（34 ± 6）,and（34 ± 4） mg.h.L-1.There were no significant differences observed（P 0.05） among the pharmacokinetic parameters between the three nationalities.Meanwhile,the pharmacokinetic parameters calculated according sex showed that the values ρmax（male（4.3 ± 0.5） vs.female（5.3 ± 0.7） mg.L-1,P 0.01） and Vd（male（65 ± 10） vs.female（51 ± 8） L,P 0.01）for modafinil and tmax（male（2.5 ± 0.9） vs.female（3.4 ± 1.1） h,P 0.05） and ρmax（male（2.8 ± 0.5） vs.female（3.3 ± 0.7） mg.L-1,P 0.05） for modafinil acid exhibited statistically significant differences.CONCLUSION Nationality has no significant impact on the pharmacokinetic parameters in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality after a single dose of modafinil tablets.However,there is some pharmacokinetic differences related to sex,which suggests possible requirements of dosage adjustments for sex difference.
其他摘要	AIM To study the pharmacokinetics of modafinil tablets in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality.METHODS Thirty healthy Chinese Mongolian,Uygur and Hui volunteers（10 for every nationality,half males,half females） were given modafinil 200 mg,and the plasma samples were collected and determined by HPLC-UV method.The main pharmacokinetic parameters of modafinil and its metabolite modafinil acid in the three nationalities and different sexes were calculated with the DAS 2.0 practical pharmacokinetic program.RESULTS After a single oral dose of modafinil 200 mg,the main pharmacokinetic parameters of modafinil for Mongolian,Uygur and Hui nationality were as follows： t1/2（13 ± s 3）,（15 ± 4）,and（14 ± 2） h;tmax（2.2 ± 0.8）,（1.8 ± 0.5）,and（1.9 ± 0.9） h;ρmax（4.9 ± 0.7）,（4.8 ± 0.7）,and（4.7 ± 1.0） mg.L-1;AUC0-∞（69 ± 12）,（71 ± 16）,and（71 ± 20） mg.h.L-1,while the pharmacokinetic parameters of modafinil acid of the above three nationalities were： t1/2（5.2 ± 1.2）,（7.2 ± 0.7）,and（7.1 ± 1.8） h;tmax（2.9 ± 0.9）,（3.1 ± 1.3）,and（2.9 ± 1.1） h;ρmax（3.5 ± 0.8）,（2.8 ± 0.4）,and （2.8 ± 0.5） mg.L-1;AUC0-∞（34 ± 8）,（34 ± 6）,and（34 ± 4） mg.h.L-1.There were no significant differences observed（P 0.05） among the pharmacokinetic parameters between the three nationalities.Meanwhile,the pharmacokinetic parameters calculated according sex showed that the values ρmax（male（4.3 ± 0.5） vs.female（5.3 ± 0.7） mg.L-1,P 0.01） and Vd（male（65 ± 10） vs.female（51 ± 8） L,P 0.01）for modafinil and tmax（male（2.5 ± 0.9） vs.female（3.4 ± 1.1） h,P 0.05） and ρmax（male（2.8 ± 0.5） vs.female（3.3 ± 0.7） mg.L-1,P 0.05） for modafinil acid exhibited statistically significant differences.CONCLUSION Nationality has no significant impact on the pharmacokinetic parameters in healthy Chinese volunteers of Mongolian,Uygur,and Hui nationality after a single dose of modafinil tablets.However,there is some pharmacokinetic differences related to sex,which suggests possible requirements of dosage adjustments for sex difference.
关键词	莫达非尼蒙古族维吾尔族回族药动学色谱法高压液相
收录类别	CSCD
语种	中文
CSCD记录号	CSCD:4085846
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156190
专题	中国科学院金属研究所
作者单位	1.沈阳药科大学 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhao Longshan,Guo Tao,Xia Dongya. Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers[J]. 中国新药与临床杂志,2010,000(011):822-826.
APA	Zhao Longshan,Guo Tao,&Xia Dongya.(2010).Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers.中国新药与临床杂志,000(011),822-826.
MLA	Zhao Longshan,et al."Pharmacokinetics of modafinil tablets in Chinese Mongolian, Uygur,and Hui healthy volunteers".中国新药与临床杂志 000.011(2010):822-826.