| Synthesis and antibacterial activities of erythromycin derivatives | |
| Alternative Title | Synthesis and Antibacterial Activities of Erythromycin Derivatives |
| Feng RL; Gong P; Fang L; Hong W | |
| 2005 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 21Issue:2Pages:177-182 |
| Abstract | Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation. Their structures were confirmed by MS and C-13 NMR; the synthetic condition (reaction medium)was explored; and their in vtiro antibacterial activities were tested. Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A. Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy. But no compound showed bactericidal activity. |
| Other Abstract | Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation. Their structures were confirmed by MS and 13C NMR; the synthetic condition(reaction medium)was explored; and their in vtiro antibacterial activities were tested. Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A. Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy. But no compound showed bactericidal activity. |
| Keyword | erythromycin derivatives synthesis antibacterial activities |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:1922820 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/156281 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Feng RL,Gong P,Fang L,et al. Synthesis and antibacterial activities of erythromycin derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2005,21(2):177-182. |
| APA | Feng RL,Gong P,Fang L,&Hong W.(2005).Synthesis and antibacterial activities of erythromycin derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,21(2),177-182. |
| MLA | Feng RL,et al."Synthesis and antibacterial activities of erythromycin derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 21.2(2005):177-182. |
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