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Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel
Alternative TitleComparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel
Tang XiaoFang1; Han YaLing3; Zhang JiaHui1; Wang Jing1; Zhang Yin1; Xu Bo1; Gao Zhan1; Qiao ShuBin1; Chen Jue1; Wu Yuan1; Chen JiLin1; Gao RunLin1; Yang YueJin1; Yuan JinQing1
2015
Source PublicationChinese Medical Journal
ISSN0366-6999
Volume128Issue:6Pages:774-779
AbstractBackground: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P < 0.001). ROC-curve analysis demonstrated that LTA (area under the curve AUC: 0.677; 95% confidence interval CI: 0.643-0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI: 0.650-0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P < 0.001), and by TEG (6.7% vs. 2.6%; P < 0.001). Kaplan-Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.
Other AbstractBackground: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P < 0.001). ROC-curve analysis demonstrated that LTA (area under the curve AUC: 0.677; 95% confidence interval CI : 0.643–0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI : 0.650–0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P < 0.001), and by TEG (6.7% vs. 2.6%; P < 0.001). Kaplan–Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.
KeywordClopidogrel Medicine R High On-treatment Platelet Reactivity Light Transmittance Aggregometry Thrombelastography
Indexed ByCSCD
Language英语
Funding Project[National Research Key Project of the Twelfth Five-year Plan of Republic of China] ; [National Natural Science Foundation of China] ; [National Special Fund for Healthcare Research in the Public Interests of China]
CSCD IDCSCD:5363387
Citation statistics
Cited Times:8[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/156495
Collection中国科学院金属研究所
Affiliation1.阜外心血管病医院
2.Peking Union Med Coll, Beijing 100037, Peoples R China
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Tang XiaoFang,Han YaLing,Zhang JiaHui,et al. Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel[J]. Chinese Medical Journal,2015,128(6):774-779.
APA Tang XiaoFang.,Han YaLing.,Zhang JiaHui.,Wang Jing.,Zhang Yin.,...&Yuan JinQing.(2015).Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel.Chinese Medical Journal,128(6),774-779.
MLA Tang XiaoFang,et al."Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel".Chinese Medical Journal 128.6(2015):774-779.
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