Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel

IMR OpenIR

	Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel
其他题名	Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel
	Tang XiaoFang 1; Han YaLing 3; Zhang JiaHui 1; Wang Jing 1; Zhang Yin 1; Xu Bo 1; Gao Zhan 1; Qiao ShuBin 1; Chen Jue 1; Wu Yuan 1; Chen JiLin 1; Gao RunLin 1; Yang YueJin 1; Yuan JinQing 1
	2015
发表期刊	Chinese Medical Journal
ISSN	0366-6999
卷号	128 期号:6 页码:774-779
摘要	Background: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P < 0.001). ROC-curve analysis demonstrated that LTA (area under the curve AUC: 0.677; 95% confidence interval CI: 0.643-0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI: 0.650-0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P < 0.001), and by TEG (6.7% vs. 2.6%; P < 0.001). Kaplan-Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.
其他摘要	Background: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P < 0.001). ROC-curve analysis demonstrated that LTA (area under the curve AUC: 0.677; 95% confidence interval CI : 0.643–0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI : 0.650–0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P < 0.001), and by TEG (6.7% vs. 2.6%; P < 0.001). Kaplan–Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.
关键词	Clopidogrel Medicine R High On-treatment Platelet Reactivity Light Transmittance Aggregometry Thrombelastography
收录类别	CSCD
语种	英语
资助项目	[National Research Key Project of the Twelfth Five-year Plan of Republic of China] ; [National Natural Science Foundation of China] ; [National Special Fund for Healthcare Research in the Public Interests of China]
CSCD记录号	CSCD:5363387
引用统计	被引频次：8[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156495
专题	中国科学院金属研究所
作者单位	1.阜外心血管病医院 2.Peking Union Med Coll, Beijing 100037, Peoples R China 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Tang XiaoFang,Han YaLing,Zhang JiaHui,et al. Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel[J]. Chinese Medical Journal,2015,128(6):774-779.
APA	Tang XiaoFang.,Han YaLing.,Zhang JiaHui.,Wang Jing.,Zhang Yin.,...&Yuan JinQing.(2015).Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel.Chinese Medical Journal,128(6),774-779.
MLA	Tang XiaoFang,et al."Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel".Chinese Medical Journal 128.6(2015):774-779.