Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives

IMR OpenIR

	Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives
其他题名	Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives
	Liao Huimin; Chong Liane; Tan Li; Chen Xiaodan; You Rui; Gong Ping
	2014
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	30 期号:5 页码:759-763
摘要	A series of novel 5,7-diphenylimidazo1,2-apyridine derivatives was designed and synthesized. The in vitro cytotoxic activities of all the target compounds against human colorectal cancer(HT-29), human lung cancer(H460), human gastric cancer(MKN45) and human breast cancer(MDA-MB-231) cell lines were evaluated. The pharmacological results indicated that most of the target compounds showed moderate to excellent activities against the tested cell lines. The most promising compound 4h(0.20, 0.006, 0.08, 0.021 mu mol/L) was 2.6, 5.1, 3.6 and 21.9 times more active than EPC2407(0.52, 0.031, 0.29, 0.46 mu mol/L) against HT-29, H460, MKN45 and MDA-MB-231 cell lines, respectively.
其他摘要	A series of novel 5,7-diphenylimidazo1,2-apyridine derivatives was designed and synthesized. The in vitro cytotoxic activities of all the target compounds against human colorectal cancer (HT-29), human lung can-cer (H460), human gastric cancer (MKN45) and human breast cancer (MDA-MB-231) cell lines were evaluated. The pharmacological results indicated that most of the target compounds showed moderate to excellent activities against the tested cell lines. The most promising compound 4h (0.20, 0.006, 0.08, 0.021 μmol/L) was 2.6, 5.1, 3.6 and 21.9 times more active than EPC2407 (0.52, 0.031, 0.29, 0.46 μmol/L) against HT-29, H460, MKN45 and MDA-MB-231 cell lines, respectively.
关键词	AGENTS Imidazo1,2-apyridine Biological evaluation Antitumor activity
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:5259969
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156538
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Liao Huimin,Chong Liane,Tan Li,et al. Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(5):759-763.
APA	Liao Huimin,Chong Liane,Tan Li,Chen Xiaodan,You Rui,&Gong Ping.(2014).Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(5),759-763.
MLA	Liao Huimin,et al."Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo1,2-apyridine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.5(2014):759-763.