Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead

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	Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead
其他题名	Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead ★
	You Yuanyuan 1; Sun Liguang 1; Peng Bo 2; Li Yan 1; Ben Songbin 3; Gao Shuang 2
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:25 页码:1939-1945
摘要	Disrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders. Developmental lead exposure can cause neurological disorders similar to hyperactivity disorder, dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo, on hippocampal Disrupted-In-Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1-10 mu M lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein expression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01-1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 expression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons.
其他摘要	Disrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders. Developmental lead exposure can cause neurological disorders similar to hyperactivity disorder, dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo , on hippocampal Disrupted-In- Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1–10 μM lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein expression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01–1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 expression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons.
关键词	AMYLOID PRECURSOR PROTEIN NEWLY GENERATED NEURONS MORRIS WATER MAZE ADULT BRAIN DISC1 NEUROGENESIS MIGRATION CHILDREN lead exposure Disrupted-In-Schizophrenia 1 hippocampus neuron neurotoxicity synapse neural regeneration
收录类别	CSCD
语种	英语
资助项目	[National Nature Science Foundation of China] ; [Foundation from China Medical University]
CSCD记录号	CSCD:4648162
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156553
专题	中国科学院金属研究所
作者单位	1.中国科学院地质与地球物理研究所 2.中国科学院金属研究所 3.辽宁大学
推荐引用方式 GB/T 7714	You Yuanyuan,Sun Liguang,Peng Bo,et al. Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1939-1945.
APA	You Yuanyuan,Sun Liguang,Peng Bo,Li Yan,Ben Songbin,&Gao Shuang.(2012).Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead.NEURAL REGENERATION RESEARCH,7(25),1939-1945.
MLA	You Yuanyuan,et al."Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead".NEURAL REGENERATION RESEARCH 7.25(2012):1939-1945.