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Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead
Alternative TitleIncreased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead ★
You Yuanyuan1; Sun Liguang1; Peng Bo2; Li Yan1; Ben Songbin3; Gao Shuang2
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:25Pages:1939-1945
AbstractDisrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders. Developmental lead exposure can cause neurological disorders similar to hyperactivity disorder, dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo, on hippocampal Disrupted-In-Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1-10 mu M lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein expression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01-1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 expression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons.
Other AbstractDisrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders. Developmental lead exposure can cause neurological disorders similar to hyperactivity disorder, dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo , on hippocampal Disrupted-In- Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1–10 μM lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein expression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01–1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 expression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons.
KeywordAMYLOID PRECURSOR PROTEIN NEWLY GENERATED NEURONS MORRIS WATER MAZE ADULT BRAIN DISC1 NEUROGENESIS MIGRATION CHILDREN lead exposure Disrupted-In-Schizophrenia 1 hippocampus neuron neurotoxicity synapse neural regeneration
Indexed ByCSCD
Language英语
Funding Project[National Nature Science Foundation of China] ; [Foundation from China Medical University]
CSCD IDCSCD:4648162
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/156553
Collection中国科学院金属研究所
Affiliation1.中国科学院地质与地球物理研究所
2.中国科学院金属研究所
3.辽宁大学
Recommended Citation
GB/T 7714
You Yuanyuan,Sun Liguang,Peng Bo,et al. Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1939-1945.
APA You Yuanyuan,Sun Liguang,Peng Bo,Li Yan,Ben Songbin,&Gao Shuang.(2012).Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead.NEURAL REGENERATION RESEARCH,7(25),1939-1945.
MLA You Yuanyuan,et al."Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead".NEURAL REGENERATION RESEARCH 7.25(2012):1939-1945.
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