Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura

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	Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura
其他题名	Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura ☆
	Liu Ruozhuo 1; Yu Shengyuan 1; Li Fengpeng 2; Qiu Enchao 1
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:25 页码:1931-1938
摘要	Cortical spreading depression can trigger migraine with aura and activate the trigeminal vascular system. To examine gene expression profiles in the spinal trigeminal nucleus in rats following cortical spreading depression-induced migraine with aura, a rat model was established by injection of 1 M potassium chloride, which induced cortical spreading depression. DNA microarray analysis revealed that, compared with the control group, the cortical spreading depression group showed seven upregulated genes-myosin heavy chain 1/2, myosin light chain 1, myosin light chain (phosphorylatable, fast skeletal muscle), actin alpha 1, homeobox B8, carbonic anhydrase 3 and an unknown gene. Two genes were downregulated-RGD1563441 and an unknown gene. Real-time quantitative reverse transcription-PCR and bioinformatics analysis indicated that these genes are involved in motility, cell migration, CO2/nitric oxide homeostasis and signal transduction.
其他摘要	Cortical spreading depression can trigger migraine with aura and activate the trigeminal vascular system. To examine gene expression profiles in the spinal trigeminal nucleus in rats following cortical spreading depression-induced migraine with aura, a rat model was established by injection of 1 M potassium chloride, which induced cortical spreading depression. DNA microarray analysis revealed that, compared with the control group, the cortical spreading depression group showed seven upregulated genes–myosin heavy chain 1 2
关键词	CORTICAL SPREADING DEPRESSION NITRIC-OXIDE INDUCTION PARKIN HOXB8 RING migraine with aura cortical spreading depression spinal nucleus of trigeminal nerve nervous system potassium chloride gene expression cell migration ubiquitin degradation enzyme regeneration neural regeneration
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4648161
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156626
专题	中国科学院金属研究所
作者单位	1.中国人民解放军总医院 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Liu Ruozhuo,Yu Shengyuan,Li Fengpeng,et al. Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1931-1938.
APA	Liu Ruozhuo,Yu Shengyuan,Li Fengpeng,&Qiu Enchao.(2012).Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura.NEURAL REGENERATION RESEARCH,7(25),1931-1938.
MLA	Liu Ruozhuo,et al."Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura".NEURAL REGENERATION RESEARCH 7.25(2012):1931-1938.