Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia

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	Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
其他题名	Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
	Qin Haiming; Song Fulin; Han Hongguang; Qu Hong; Zhai Xingwen; Qin Bin; You Song
	2011
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	6 期号:27 页码:2105-2111
摘要	The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.
其他摘要	The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins
关键词	ARTERY OCCLUSION WATER CHANNELS EXTRACT EGB-761 EDEMA NEUROPROTECTION PERMEABILITY ASTROCYTES PROTECTION MEMBRANE INJURY bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration
收录类别	CSCD
语种	英语
资助项目	[General Hospital of Shenyang Military Area Command of Chinese PLA] ; [Foundation of General Hospital of Shenyang Military Area Command of Chinese PLA]
CSCD记录号	CSCD:4363518
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156681
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Qin Haiming,Song Fulin,Han Hongguang,et al. Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J]. NEURAL REGENERATION RESEARCH,2011,6(27):2105-2111.
APA	Qin Haiming.,Song Fulin.,Han Hongguang.,Qu Hong.,Zhai Xingwen.,...&You Song.(2011).Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia.NEURAL REGENERATION RESEARCH,6(27),2105-2111.
MLA	Qin Haiming,et al."Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia".NEURAL REGENERATION RESEARCH 6.27(2011):2105-2111.