Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

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	Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
其他题名	Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
	Fu Li Qiang 1; Guo Xing Sheng 2; Liu Xin 1; He Hui Li 1; Wang Yu Ling 2; Yang Yu She 1
	2010
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	21 期号:5 页码:507-510
摘要	In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved
其他摘要	In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity, a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
关键词	PATHOGENS Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3892707
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156713
专题	中国科学院金属研究所
作者单位	1.中国科学院 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Fu Li Qiang,Guo Xing Sheng,Liu Xin,et al. Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(5):507-510.
APA	Fu Li Qiang,Guo Xing Sheng,Liu Xin,He Hui Li,Wang Yu Ling,&Yang Yu She.(2010).Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives.CHINESE CHEMICAL LETTERS,21(5),507-510.
MLA	Fu Li Qiang,et al."Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives".CHINESE CHEMICAL LETTERS 21.5(2010):507-510.