Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats

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	Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats
其他题名	Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats ☆
	Ren Guiru; Kong Jingjing; Jia Ning; Shang Xiuli
	2013
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	8 期号:12 页码:1071-1080
摘要	Luteolin (3',4',5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment (given twice daily for 15 days) significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin-induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abilities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway.
其他摘要	Luteolin (3’,4’,5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment (given twice daily for 15 days) significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin-induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abilities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase
关键词	OXIDATIVE STRESS CELL-DEATH DYSFUNCTION DISEASE neural regeneration brain injury diabetic mellitus luteolin apoptosis learning and memory spatial recognition memory nerve cells hippocampus anti-oxidation neuroregeneration
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4818406
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/156910
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Ren Guiru,Kong Jingjing,Jia Ning,et al. Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats[J]. NEURAL REGENERATION RESEARCH,2013,8(12):1071-1080.
APA	Ren Guiru,Kong Jingjing,Jia Ning,&Shang Xiuli.(2013).Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats.NEURAL REGENERATION RESEARCH,8(12),1071-1080.
MLA	Ren Guiru,et al."Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats".NEURAL REGENERATION RESEARCH 8.12(2013):1071-1080.