Alternative TitlePreliminary study of performance of peripheral absorbable magnesium alloy stent
肖耀文1; 陈忠1; 杨耀国1; 寇镭1; 郑丰2; 张炳春2; 白树功1; 郑焕勤1; 刘博文1; 王艳阳1
Source Publication中华放射学杂志
Other AbstractObjective To investigate the performance and safety of domestic peripherally absorbable magnesium alloy stent. Methods Sixteen absorbable magnesium alloy stents were implanted in the bilateral iliac-femoral arteries of 8 Chinese Agricultural University minipigs selected randomly with computer.The mean weight was (21.19±1.93)kg. One pig was randomly selected by computer on 30^th, 45^th, 60^th, 75^th, 90^th, 105^th, 120^th and 135^th days after stent implantation and both stents were removed. The biochemical, imaging and histopathology index of the pig before and after stent placement were analyzed, t test was used to compare data collected before and after stenting. Results The biochemical index changes showed no statistical significance after stent implantation, the DSA indicated that vessel diameter was (4.39±0.26) mm before stent implantation and (3.85±0.71)mm on the 30^th to 135^th day afterimplatation (t= 3.041, P= 0.008), the balance of vessel diameter before and after stenting ranged from 0 to 2.29 mm, with minimun on 30^th day, and maximum on 90^th day; HE and verhoeffvangieson showed significant stenosis of the arteries occurred on 60^th, 90^th and 120^th day. From the 30^th day to 135^th day after stenting, the average diameter of residual lumen was (1.38±0.18) mm, the average area of residual lumen was ( 1.51±0.41 )mm^2, the average area of internal elastic lamina was (1.91±0.22) mm^2, the average area of external elastic lamina was (4.79± 0.79) mm^2, the average thickness of endothelium was (0.11 ±0.06) mm, the average area of new intima was (0.40±0.29) mm^2, the average narrow area percentage was (21.96±16.48)%.The stent absorbed gradually, and not completely absorbed until 135^th day after stenting. Endometrial cells completely covered stent surface, and the stent did not break or collapse at all. Conclusions The peripherally absorbable magnesium alloy stents is safe and effective in animal experiment. Application of this stent in human should be investigated with further studies.
Keyword髂动脉 支架 镁化合物 移植物闭塞 血管 动物实验
Indexed ByCSCD
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Document Type期刊论文
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GB/T 7714
肖耀文,陈忠,杨耀国,等. 外周动脉可吸收镁合金支架性能初探[J]. 中华放射学杂志,2016,0.0(8.0):625-629.
APA 肖耀文.,陈忠.,杨耀国.,寇镭.,郑丰.,...&王艳阳.(2016).外周动脉可吸收镁合金支架性能初探.中华放射学杂志,0.0(8.0),625-629.
MLA 肖耀文,et al."外周动脉可吸收镁合金支架性能初探".中华放射学杂志
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