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Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives
Alternative TitleSynthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3- bpyrazin-3(4 H)-one derivatives
Zhang Guo Gang; Liu Ya Jing; Ma Xiao Guang; Dong Hao; Li Ju; Gong Ping
2011
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume22Issue:10Pages:1223-1225
AbstractA series of novel 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that compounds 5b, 5c, 10a and 10g possessed marked cytotoxicity, especially 10a (with IC50 values of 0.81, 2.56 and 1.63 mu mol/L against A549, MDA-MB-231 and HT29 cell lines, respectively), which had emerged as a lead compound. (C) 2011 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of novel 2-hydrazinylpyrido2, 3-bpyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that compounds 5b, 5c, 10a and 10g possessed marked cytotoxicity, especially 10a (with IC_(50) values of 0.81, 2.56 and 1.63μmol/L against A549, MDA-MB-231 and HT29 cell lines, respectively), which had emerged as a lead compound.
KeywordPYRIDOPYRIMIDINES 2-Hydrazinylpyrido2,3-bpyrazin-3(4H)-ones Synthesis Cytotoxicity
Indexed ByCSCD
Language英语
Funding Project[National S & T Major Project of China]
CSCD IDCSCD:4342794
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/157070
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang Guo Gang,Liu Ya Jing,Ma Xiao Guang,et al. Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives[J]. CHINESE CHEMICAL LETTERS,2011,22(10):1223-1225.
APA Zhang Guo Gang,Liu Ya Jing,Ma Xiao Guang,Dong Hao,Li Ju,&Gong Ping.(2011).Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives.CHINESE CHEMICAL LETTERS,22(10),1223-1225.
MLA Zhang Guo Gang,et al."Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives".CHINESE CHEMICAL LETTERS 22.10(2011):1223-1225.
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