Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives

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	Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives
其他题名	Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3- bpyrazin-3(4 H)-one derivatives
	Zhang Guo Gang; Liu Ya Jing; Ma Xiao Guang; Dong Hao; Li Ju; Gong Ping
	2011
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	22 期号:10 页码:1223-1225
摘要	A series of novel 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that compounds 5b, 5c, 10a and 10g possessed marked cytotoxicity, especially 10a (with IC50 values of 0.81, 2.56 and 1.63 mu mol/L against A549, MDA-MB-231 and HT29 cell lines, respectively), which had emerged as a lead compound. (C) 2011 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A series of novel 2-hydrazinylpyrido2, 3-bpyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that compounds 5b, 5c, 10a and 10g possessed marked cytotoxicity, especially 10a (with IC_(50) values of 0.81, 2.56 and 1.63μmol/L against A549, MDA-MB-231 and HT29 cell lines, respectively), which had emerged as a lead compound.
关键词	PYRIDOPYRIMIDINES 2-Hydrazinylpyrido2,3-bpyrazin-3(4H)-ones Synthesis Cytotoxicity
收录类别	CSCD
语种	英语
资助项目	[National S & T Major Project of China]
CSCD记录号	CSCD:4342794
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157070
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Guo Gang,Liu Ya Jing,Ma Xiao Guang,et al. Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives[J]. CHINESE CHEMICAL LETTERS,2011,22(10):1223-1225.
APA	Zhang Guo Gang,Liu Ya Jing,Ma Xiao Guang,Dong Hao,Li Ju,&Gong Ping.(2011).Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives.CHINESE CHEMICAL LETTERS,22(10),1223-1225.
MLA	Zhang Guo Gang,et al."Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido2,3-bpyrazin-3(4H)-one derivatives".CHINESE CHEMICAL LETTERS 22.10(2011):1223-1225.