Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients

IMR OpenIR

	Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients
其他题名	Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients
	Lin Yi 1; Wang Jiangfei 2; Gao Guangzu 3; Zhang Guozhen 2; Wang Feilong 1; Wang Yunjie 1
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	126 期号:22 页码:4295-4300
摘要	Background There is no validated blood biomarker available for glioma management. Invasive growth is the key feature of glioma. We assessed the clinical usefulness of plasma tissue inhibitor of metalloproteinase 1 (TIMP-1), which has less molecular weight than metalloproteinases, as a potential blood biomarker for glioma.
其他摘要	Background There is no validated blood biomarker available for glioma management. Invasive growth is the key feature of glioma. We assessed the clinical usefulness of plasma tissue inhibitor of metalloproteinase 1 (TIMP-1), which has less molecular weight than metalloproteinases, as a potential blood biomarker for glioma. Methods A total of 285 patients and 59 normal subjects were studied. Plasma concentration of TIMP-1 was measured with enzyme-linked immunosorbent assay. Plasma TIMP-1 was compared between normal and glioma patients, between patients with different pathological grades, and between patients with different prognoses. Longitudinal changes in plasma TIMP-1 during treatment were also evaluated. Plasma matrix metalloproteinase (MMP)-9 level was also assayed and its clinical usefulness was compared with that of TIMP-1. Results Plasma TIMP-1 and MMP-9 were both increased in glioma patients compared with normal controls (TIMP-1: P <0.001; MMP-9: P=0.007). Plasma TIMP-1 increases with increased tumor grade. In Grade IV gliomas, plasma TIMP-1 significantly increased after “successful removal” of the tumor (paired samples t-test, before operation vs. during chemotherapy without recurrence, t = –2.131, P=0.038), but did not change significantly at the time of tumor recurrence (during chemotherapy without recurrence vs. after tumor recurrence, t = –0.652, P=0.632). High plasma TIMP-1 level correlated with better survival in Grade IV glioma patients (hazard ratio: 0.550, 95% CI: 0.101–1.000, P=0.036). In Grade IV gliomas, patients with higher plasma TIMP-1 had significantly longer survival time than those with lower plasma TIMP-1 level (25.23 vs. 18.95 months, log-rank P=0.045). Plasma MMP-9 did not show significant association with either the pathological grade or the prognosis of glioma patients. Conclusions Plasma TIMP-1 is associated with the diagnosis and prognosis of glioma patients. It appears to have better usefulness for guiding clinical decision making than plasma MMP-9. Further studies in an expanded patient population are needed to better define its clinical usefulness.
关键词	HIGH-GRADE GLIOMAS MALIGNANT GLIOMAS SERUM MARKER GLIOBLASTOMA PREDICTS MATRIX-METALLOPROTEINASE-9 MT1-MMP YKL-40 TUMORS MMP-2 glioma plasma biomarker tissue inhibitor of metalloproteinase 1 metalloproteinase 9
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [National High Technology Research and Development Program of China] ; [International Science and Technology Cooperation Program]
CSCD记录号	CSCD:4983975
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157234
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Capital Med Univ, Beijing Neurosurg Institute, Dept Neurosurg, Beijing 100050, Peoples R China 3.哈佛大学
推荐引用方式 GB/T 7714	Lin Yi,Wang Jiangfei,Gao Guangzu,et al. Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients[J]. CHINESE MEDICAL JOURNAL,2013,126(22):4295-4300.
APA	Lin Yi,Wang Jiangfei,Gao Guangzu,Zhang Guozhen,Wang Feilong,&Wang Yunjie.(2013).Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients.CHINESE MEDICAL JOURNAL,126(22),4295-4300.
MLA	Lin Yi,et al."Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients".CHINESE MEDICAL JOURNAL 126.22(2013):4295-4300.