| Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients | |
| Alternative Title | Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients |
| Lin Yi1; Wang Jiangfei2; Gao Guangzu3; Zhang Guozhen2; Wang Feilong1; Wang Yunjie1 | |
| 2013 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 126Issue:22Pages:4295-4300 |
| Abstract | Background There is no validated blood biomarker available for glioma management. Invasive growth is the key feature of glioma. We assessed the clinical usefulness of plasma tissue inhibitor of metalloproteinase 1 (TIMP-1), which has less molecular weight than metalloproteinases, as a potential blood biomarker for glioma. |
| Other Abstract | Background There is no validated blood biomarker available for glioma management. Invasive growth is the key feature of glioma. We assessed the clinical usefulness of plasma tissue inhibitor of metalloproteinase 1 (TIMP-1), which has less molecular weight than metalloproteinases, as a potential blood biomarker for glioma. Methods A total of 285 patients and 59 normal subjects were studied. Plasma concentration of TIMP-1 was measured with enzyme-linked immunosorbent assay. Plasma TIMP-1 was compared between normal and glioma patients, between patients with different pathological grades, and between patients with different prognoses. Longitudinal changes in plasma TIMP-1 during treatment were also evaluated. Plasma matrix metalloproteinase (MMP)-9 level was also assayed and its clinical usefulness was compared with that of TIMP-1. Results Plasma TIMP-1 and MMP-9 were both increased in glioma patients compared with normal controls (TIMP-1: P <0.001; MMP-9: P=0.007). Plasma TIMP-1 increases with increased tumor grade. In Grade IV gliomas, plasma TIMP-1 significantly increased after “successful removal” of the tumor (paired samples t-test, before operation vs. during chemotherapy without recurrence, t = –2.131, P=0.038), but did not change significantly at the time of tumor recurrence (during chemotherapy without recurrence vs. after tumor recurrence, t = –0.652, P=0.632). High plasma TIMP-1 level correlated with better survival in Grade IV glioma patients (hazard ratio: 0.550, 95% CI: 0.101–1.000, P=0.036). In Grade IV gliomas, patients with higher plasma TIMP-1 had significantly longer survival time than those with lower plasma TIMP-1 level (25.23 vs. 18.95 months, log-rank P=0.045). Plasma MMP-9 did not show significant association with either the pathological grade or the prognosis of glioma patients. Conclusions Plasma TIMP-1 is associated with the diagnosis and prognosis of glioma patients. It appears to have better usefulness for guiding clinical decision making than plasma MMP-9. Further studies in an expanded patient population are needed to better define its clinical usefulness. |
| Keyword | HIGH-GRADE GLIOMAS MALIGNANT GLIOMAS SERUM MARKER GLIOBLASTOMA PREDICTS MATRIX-METALLOPROTEINASE-9 MT1-MMP YKL-40 TUMORS MMP-2 glioma plasma biomarker tissue inhibitor of metalloproteinase 1 metalloproteinase 9 |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [National High Technology Research and Development Program of China] ; [International Science and Technology Cooperation Program] |
| CSCD ID | CSCD:4983975 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/157234 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Capital Med Univ, Beijing Neurosurg Institute, Dept Neurosurg, Beijing 100050, Peoples R China 3.哈佛大学 |
| Recommended Citation GB/T 7714 | Lin Yi,Wang Jiangfei,Gao Guangzu,et al. Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients[J]. CHINESE MEDICAL JOURNAL,2013,126(22):4295-4300. |
| APA | Lin Yi,Wang Jiangfei,Gao Guangzu,Zhang Guozhen,Wang Feilong,&Wang Yunjie.(2013).Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients.CHINESE MEDICAL JOURNAL,126(22),4295-4300. |
| MLA | Lin Yi,et al."Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients".CHINESE MEDICAL JOURNAL 126.22(2013):4295-4300. |
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