| Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling | |
| Alternative Title | Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling ★ |
| Ma Yinghuan1; Bao Yongxin1; Li Chenghao1; Jiao Fubin2; Xin Hongjie1; Yuan Zhengwei1 | |
| 2012 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 7Issue:32Pages:2485-2491 |
| Abstract | Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofiuorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway. |
| Other Abstract | Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway. |
| Keyword | NEURAL-TUBE DEFECTS PROGRAMMED CELL-DEATH EMBRYONIC-DEVELOPMENT INDUCED APOPTOSIS CASPASE 9 IN-VIVO ACTIVATION MECHANISMS PATHWAYS MICE retinoic acid neural tube defects myeloid tissues caspase-3 apoptotic kinase c-Jun N-terminal kinase mitogen-activated protein kinase neural development regeneration neural regeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4694378 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/157513 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Gen Advisor Off Chinese PLA, Bur Guard, Div Hlth, Beijing 100017, Peoples R China Bur Guard Div Hlth |
| Recommended Citation GB/T 7714 | Ma Yinghuan,Bao Yongxin,Li Chenghao,et al. Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling[J]. NEURAL REGENERATION RESEARCH,2012,7(32):2485-2491. |
| APA | Ma Yinghuan,Bao Yongxin,Li Chenghao,Jiao Fubin,Xin Hongjie,&Yuan Zhengwei.(2012).Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.NEURAL REGENERATION RESEARCH,7(32),2485-2491. |
| MLA | Ma Yinghuan,et al."Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling".NEURAL REGENERATION RESEARCH 7.32(2012):2485-2491. |
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