Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling

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	Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling
其他题名	Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling ★
	Ma Yinghuan 1; Bao Yongxin 1; Li Chenghao 1; Jiao Fubin 2; Xin Hongjie 1; Yuan Zhengwei 1
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:32 页码:2485-2491
摘要	Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofiuorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.
其他摘要	Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.
关键词	NEURAL-TUBE DEFECTS PROGRAMMED CELL-DEATH EMBRYONIC-DEVELOPMENT INDUCED APOPTOSIS CASPASE 9 IN-VIVO ACTIVATION MECHANISMS PATHWAYS MICE retinoic acid neural tube defects myeloid tissues caspase-3 apoptotic kinase c-Jun N-terminal kinase mitogen-activated protein kinase neural development regeneration neural regeneration
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4694378
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157513
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Gen Advisor Off Chinese PLA, Bur Guard, Div Hlth, Beijing 100017, Peoples R China Bur Guard Div Hlth
推荐引用方式 GB/T 7714	Ma Yinghuan,Bao Yongxin,Li Chenghao,et al. Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling[J]. NEURAL REGENERATION RESEARCH,2012,7(32):2485-2491.
APA	Ma Yinghuan,Bao Yongxin,Li Chenghao,Jiao Fubin,Xin Hongjie,&Yuan Zhengwei.(2012).Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.NEURAL REGENERATION RESEARCH,7(32),2485-2491.
MLA	Ma Yinghuan,et al."Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling".NEURAL REGENERATION RESEARCH 7.32(2012):2485-2491.