Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety

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	Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety
其他题名	Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety
	Zhang Bei; Zhao Yan Fang; Zhai Xin; Fan Wei Jie; Ren Jun Ling; Wu Chun Fu; Gong Ping
	2012
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	23 期号:8 页码:915-918
摘要	A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line (HL-60), human lung adenocarcinoma epithelial cell line (A549) and human breast cancer cell line (MDA-MB-231) in vitro by standard MTT assay. The pharmacological results indicated that some compounds exhibited promising antitumor activities. Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC50 values of 0.13 mu mol/L, 0.7 mu mol/L and 0.5 mu mol/L, respectively. (C) 2012 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line(HL-60),human lung adenocarcinoma epithelial cell line(A549) and human breast cancer cell line(MDA-MB-231) in vitro by standard MTT assay.The pharmacological results indicated that some compounds exhibited promising antitumor activities.Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC values of 0.13 mmol/L,0.7 mmol/L and 0.5 mmol/L,respectively.
关键词	RAF/MEK/ERK PATHWAY DUAL-ACTION INHIBITORS TARGETS SORAFENIB CANCER Diaryl ureas N-acylhydrazone Antiproliferative activities
收录类别	CSCD
语种	英语
资助项目	[National High Technology Research and Development Program ("863" Program) of China] ; [National Natural Science Foundation of China] ; [Shenyang Science and Technology Plan Projects]
CSCD记录号	CSCD:4601190
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157579
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Bei,Zhao Yan Fang,Zhai Xin,et al. Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety[J]. CHINESE CHEMICAL LETTERS,2012,23(8):915-918.
APA	Zhang Bei.,Zhao Yan Fang.,Zhai Xin.,Fan Wei Jie.,Ren Jun Ling.,...&Gong Ping.(2012).Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety.CHINESE CHEMICAL LETTERS,23(8),915-918.
MLA	Zhang Bei,et al."Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety".CHINESE CHEMICAL LETTERS 23.8(2012):915-918.