Genetic diversity of coronaviruses in Miniopterus fuliginosus bats

IMR OpenIR

	Genetic diversity of coronaviruses in Miniopterus fuliginosus bats
其他题名	Genetic diversity of coronaviruses in Miniopterus fuliginosus bats
	Du Jiang 1; Yang Li 1; Ren Xianwen 1; Zhang Junpeng 3; Dong Jie 1; Sun Lilian 1; Zhu Yafang 1; Yang Fan 1; Zhang Shuyi 4; Wu Zhiqiang 1; Jin Qi 1
	2016
发表期刊	Science China. Life Sciences
ISSN	1674-7305
卷号	59 期号:6 页码:604-614
摘要	Coronaviruses, such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose significant public health threats. Bats have been suggested to act as natural reservoirs for both these viruses, and periodic monitoring of coronaviruses in bats may thus provide important clues about emergent infectious viruses. The Eastern bent-wing bat Miniopterus fuliginosus is distributed extensively throughout China. We therefore analyzed the genetic diversity of coronaviruses in samples of M. fuliginosus collected from nine Chinese provinces during 2011–2013. The only coronavirus genus found was Alphacoronavirus . We established six complete and five partial genomic sequences of alphacoronaviruses, which revealed that they could be divided into two distinct lineages, with close relationships to coronaviruses in Miniopterus magnater and Miniopterus pusillus . Recombination was confirmed by detecting putative breakpoints of Lineage 1 coronaviruses in M. fuliginosus and M. pusillus (Wu et al., 2015), which supported the results of topological and phylogenetic analyses. The established alphacoronavirus genome sequences showed high similarity to other alphacoronaviruses found in other Miniopterus species, suggesting that their transmission in different Miniopterus species may provide opportunities for recombination with different alphacoronaviruses. The genetic information for these novel alphacoronaviruses will improve our understanding of the evolution and genetic diversity of coronaviruses, with potentially important implications for the transmission of human diseases.
其他摘要	Coronaviruses, such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose significant public health threats. Bats have been suggested to act as natural reservoirs for both these viruses, and periodic monitoring of coronaviruses in bats may thus provide important clues about emergent infectious viruses. The Eastern bent-wing bat Miniopterus fuliginosus is distributed extensively throughout China. We therefore analyzed the genetic diversity of coronaviruses in samples of M. fuliginosus collected from nine Chinese provinces during 2011–2013. The only coronavirus genus found was Alphacoronavirus . We established six complete and five partial genomic sequences of alphacoronaviruses, which revealed that they could be divided into two distinct lineages, with close relationships to coronaviruses in Miniopterus magnater and Miniopterus pusillus . Recombination was confirmed by detecting putative breakpoints of Lineage 1 coronaviruses in M. fuliginosus and M. pusillus (Wu et al., 2015), which supported the results of topological and phylogenetic analyses. The established alphacoronavirus genome sequences showed high similarity to other alphacoronaviruses found in other Miniopterus species, suggesting that their transmission in different Miniopterus species may provide opportunities for recombination with different alphacoronaviruses. The genetic information for these novel alphacoronaviruses will improve our understanding of the evolution and genetic diversity of coronaviruses, with potentially important implications for the transmission of human diseases.
关键词	RESPIRATORY SYNDROME CORONAVIRUS AVIAN CORONAVIRUSES MAXIMUM-LIKELIHOOD PROTEIN FAMILIES COMPLETE GENOME RECOMBINATION VIRUS ALPHACORONAVIRUS BETACORONAVIRUS EXPRESSION coronavirus Miniopterus fuliginosus bat co-infection recombination
收录类别	CSCD
语种	英语
资助项目	[Program for Changjiang Scholars and Innovative Research Team in University of China] ; [National S&T Major Project "China Mega-Project for Infectious Disease" from China] ; [National Natural Science Foundation of China] ; [PUMC Youth Fund] ; [Fundamental Research Funds for the Central Universities]
CSCD记录号	CSCD:5712853
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157761
专题	中国科学院金属研究所
作者单位	1.中国科学院系统生物学重点实验室 2.Peking Union Med Coll, Beijing 100176, Peoples R China 3.E China Normal Univ, Institute Estuarine & Coastal Res, State Key Lab Estuarine & Coastal Res, Shanghai 200062, Peoples R China 4.中国科学院金属研究所 5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Du Jiang,Yang Li,Ren Xianwen,et al. Genetic diversity of coronaviruses in Miniopterus fuliginosus bats[J]. Science China. Life Sciences,2016,59(6):604-614.
APA	Du Jiang.,Yang Li.,Ren Xianwen.,Zhang Junpeng.,Dong Jie.,...&Jin Qi.(2016).Genetic diversity of coronaviruses in Miniopterus fuliginosus bats.Science China. Life Sciences,59(6),604-614.
MLA	Du Jiang,et al."Genetic diversity of coronaviruses in Miniopterus fuliginosus bats".Science China. Life Sciences 59.6(2016):604-614.