Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction

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	Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction
其他题名	Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction
	Jian Yong; Li Gang; Yang Peng; Deng Tuo; Zhou Xue; Xu Haiyan
	2014
发表期刊	CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN	0253-2786
卷号	34 期号:4 页码:809-816
摘要	A series of carbazole derivatives were synthesized via reactions of C-N bond formation catalyzed by CuBr center dot SMe2, nitration, reduction as well as Pd-catalyzed C-N crossing coupling, respectively. Their UV-Vis and fluorescence spectra in different solvents were investigated, as well as the evaluation of the interaction between compound 2 hydrochloride and Ct-DNA. The results showed that all compounds exhibited distinct solvatochromism effects and among them, compound 4 was the most obvious one. Upon binding with DNA, the fluorescence of compound 2 hydrochloride turned on, instead of quenching, and the minor groove of DNA is the most possible position for the molecule to bind with. The calculated binding constant is around 10(4) L.mol(-1), showing a moderate binding affinity.
关键词	PHOTOPHYSICAL PROPERTIES NUCLEIC-ACIDS BINDING DESIGN DYES carbazole C-N cross coupling solvatochromism spectral properties Ct-DNA
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Liaoning Provincial Natural Science Foundation] ; [Program of Liaoning Excellent Talents in University] ; [Liaoning Provincial Postdoctoral Converging Project] ; [Undergraduates Innovative Entrepreneurship Training Project of Liaoning Province]
CSCD记录号	CSCD:5133406
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157802
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Jian Yong,Li Gang,Yang Peng,et al. Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2014,34(4):809-816.
APA	Jian Yong,Li Gang,Yang Peng,Deng Tuo,Zhou Xue,&Xu Haiyan.(2014).Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction.CHINESE JOURNAL OF ORGANIC CHEMISTRY,34(4),809-816.
MLA	Jian Yong,et al."Syntheses, Spectral Properties of Novel Carbazole Derivatives and Evaluations of Its Ct-DNA Interaction".CHINESE JOURNAL OF ORGANIC CHEMISTRY 34.4(2014):809-816.