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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design
Alternative TitleImmunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design
Gao Yang1; Tian Wen1; Han Xiaoxu1; Gao Feng2
2017
Source PublicationFRONTIERS OF MEDICINE
ISSN2095-0217
Volume11Issue:4Pages:480-489
AbstractSuperinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
Other AbstractSuperinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
KeywordNEUTRALIZING ANTIBODY-RESPONSE RAPID DISEASE PROGRESSION INTRAVENOUS-DRUG-USERS HIV-1 DUAL INFECTION FEMALE SEX WORKERS T-CELL RESPONSES ANTIRETROVIRAL THERAPY AMSTERDAM COHORT HOMOSEXUAL-MEN HIGH-RISK human immunodeficiency virus type I superinfection incidence immune response
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Program for JLU Science and Technology Innovative Research Team] ; [NIAID of NIH]
CSCD IDCSCD:6141297
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/157943
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.吉林大学
3.杜克大学
Recommended Citation
GB/T 7714
Gao Yang,Tian Wen,Han Xiaoxu,et al. Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design[J]. FRONTIERS OF MEDICINE,2017,11(4):480-489.
APA Gao Yang,Tian Wen,Han Xiaoxu,&Gao Feng.(2017).Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design.FRONTIERS OF MEDICINE,11(4),480-489.
MLA Gao Yang,et al."Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design".FRONTIERS OF MEDICINE 11.4(2017):480-489.
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