IMR OpenIR
Synthesis and in vitro antitumor activity of novel diaryl urea derivatives
Alternative TitleSynthesis and in vitro antitumor activity of novel diaryl urea derivatives
Zhao YanFang; Liu ZiJian; Zhai Xin; Ge DanDan; Huang Qiang; Gong Ping
2013
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume24Issue:5Pages:386-388
AbstractA series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50 values of 0.016, 0.63, 0.001 mu mol/L, respectively. (C) 2013 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_(50) values of 0.016,0.63,0.001μmol/L, respectively.
KeywordRECEPTOR TYROSINE KINASES INHIBITOR DISCOVERY SORAFENIB Diaryl ureas Synthesis Antitumor activity in vitro
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4846555
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158028
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao YanFang,Liu ZiJian,Zhai Xin,et al. Synthesis and in vitro antitumor activity of novel diaryl urea derivatives[J]. CHINESE CHEMICAL LETTERS,2013,24(5):386-388.
APA Zhao YanFang,Liu ZiJian,Zhai Xin,Ge DanDan,Huang Qiang,&Gong Ping.(2013).Synthesis and in vitro antitumor activity of novel diaryl urea derivatives.CHINESE CHEMICAL LETTERS,24(5),386-388.
MLA Zhao YanFang,et al."Synthesis and in vitro antitumor activity of novel diaryl urea derivatives".CHINESE CHEMICAL LETTERS 24.5(2013):386-388.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao YanFang]'s Articles
[Liu ZiJian]'s Articles
[Zhai Xin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao YanFang]'s Articles
[Liu ZiJian]'s Articles
[Zhai Xin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao YanFang]'s Articles
[Liu ZiJian]'s Articles
[Zhai Xin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.