Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

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	Synthesis and in vitro antitumor activity of novel diaryl urea derivatives
其他题名	Synthesis and in vitro antitumor activity of novel diaryl urea derivatives
	Zhao YanFang; Liu ZiJian; Zhai Xin; Ge DanDan; Huang Qiang; Gong Ping
	2013
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	24 期号:5 页码:386-388
摘要	A series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50 values of 0.016, 0.63, 0.001 mu mol/L, respectively. (C) 2013 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_(50) values of 0.016,0.63,0.001μmol/L, respectively.
关键词	RECEPTOR TYROSINE KINASES INHIBITOR DISCOVERY SORAFENIB Diaryl ureas Synthesis Antitumor activity in vitro
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4846555
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/158028
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhao YanFang,Liu ZiJian,Zhai Xin,et al. Synthesis and in vitro antitumor activity of novel diaryl urea derivatives[J]. CHINESE CHEMICAL LETTERS,2013,24(5):386-388.
APA	Zhao YanFang,Liu ZiJian,Zhai Xin,Ge DanDan,Huang Qiang,&Gong Ping.(2013).Synthesis and in vitro antitumor activity of novel diaryl urea derivatives.CHINESE CHEMICAL LETTERS,24(5),386-388.
MLA	Zhao YanFang,et al."Synthesis and in vitro antitumor activity of novel diaryl urea derivatives".CHINESE CHEMICAL LETTERS 24.5(2013):386-388.