Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint

IMR OpenIR

	Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint
其他题名	Diagnosis of tumor-like polypoid lesions of gallbladder by serum proteomic fingerprint
	Ge Chunlin 1; Luan Fengming 1; Ma Ning 1; Li Yongzhe 2; Hu Chaojun 2; Li Ning 2
	2008
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	20 期号:4 页码:286-289
摘要	Objective: To search the specific serum proteins in tumor-like polypoid lesions of the gallbladder(PLG) patients. Methods: Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic fingerprint of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data. Results: In the preliminary screening, 22 representative specific proteins for tumor-like PLG were found. Seven specific proteins showed increased expression and 15 specific proteins showed decreased expression in the tumor-like PLG patients. Three specific proteins are selected for the diagnosis of the tumor-like PLG.. Conclusion: SELDI-TOF-MS technique can be used to select specific proteins for tumor-like PLG patients, which may be useful for the diagnosis of the tumor-like PLG and the differential diagnosis with the non tumor-like PLG.
其他摘要	Objective To search the specific serum proteins in tumor-like polypoid lesions of the gallbladder(PLG) patients. Methods Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic fingerprint of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data. Results In the preliminary screening, 22 representative specific proteins for tumor-like PLG were found. Seven specific proteins showed increased expression and 15 specific proteins showed decreased expression in the tumor-like PLG patients. Three specific proteins are selected for the diagnosis of the tumor-like PLG. Conclusion SELDI-TOF-MS technique can be used to select specific proteins for tumor-like PLG patients, which may be useful for the diagnosis of the tumor-like PLG and the differential diagnosis with the non tumor-like PLG.
关键词	FLIGHT MASS-SPECTROMETRY SELDI-TOF-MS CANCER IDENTIFICATION DISCOVERY BIOMARKERS CARCINOMA BREAST TIME Gallbladder disease Diagnosis Specific proteins Surface enhanced laser desorption/ionization time of flight mass spectrometry
收录类别	CSCD
语种	英语
资助项目	[Scientific Research Foundation of the High School from Education Department of Liaoning Province]
CSCD记录号	CSCD:3427191
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/158089
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Beijing Union Med Coll Hosp, Peking Union Med Coll, Department Clin Lab, Beijing 100730, Peoples R China 3.中国医学科学院
推荐引用方式 GB/T 7714	Ge Chunlin,Luan Fengming,Ma Ning,et al. Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(4):286-289.
APA	Ge Chunlin,Luan Fengming,Ma Ning,Li Yongzhe,Hu Chaojun,&Li Ning.(2008).Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint.CHINESE JOURNAL OF CANCER RESEARCH,20(4),286-289.
MLA	Ge Chunlin,et al."Diagnosis of Tumor-Like Polypoid Lesions of Gallbladder by Serum Proteomic Fingerprint".CHINESE JOURNAL OF CANCER RESEARCH 20.4(2008):286-289.