Expression of TRPC6 in benign and malignant human prostate tissues

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	Expression of TRPC6 in benign and malignant human prostate tissues
其他题名	Expression of TRPC6 in benign and malignant human prostate tissues
	Yue Dan 1; Wang Yong 1; Xiao JianYing 2; Wang Ping 1; Ren ChangShan 1
	2009
发表期刊	ASIAN JOURNAL OF ANDROLOGY
ISSN	1008-682X
卷号	11 期号:5 页码:541-547
摘要	We investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. Immunohistochemical techniques, Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. TRPC6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (BPH) cases, and there was a significant difference compared with prostate cancer (129 of 149 86.6%) (P < 0.01). TRPC6 expression was associated with the histological grade and extraprostatic extension (P < 0.01). Tumors of higher stage tended to have a higher frequency of TRPC6 protein staining, but the difference was not significant among T2, T3 and T4. TRPC6 expression difference between androgen-independent (AI) tumors and androgen-dependent (AD) tumors was not statistically significant. TRPC6 was also observed in prostate cancer cell lines. In summary, TRPC6 is detected in benign and malignant human prostate tissues and prostate cancer cell lines and is associated with the histological grade, Gleason score and extraprostatic extension of prostate cancer.
其他摘要	We investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. Immunohistochemical techniques, Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. TRPC6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (BPH) cases, and there was a significant difference compared with prostate cancer (129 of 149 86.6%)( P < 0.01). TRPC6 expression was associated with the histological grade and extraprostatic extension ( P < 0.01). Tumors of higher stage tended to have a higher frequency of TRPC6 protein staining, but the difference was not significant among T2, T3 and T4. TRPC6 expression difference between androgen-independent (AI) tumors and androgen-dependent (AD) tumors was not statistically significant. TRPC6 was also observed in prostate cancer cell lines. In summary, TRPC6 is detected in benign and malignant human prostate tissues and prostate cancer cell lines and is associated with the histological grade, Gleason score and extraprostatic extension of prostate cancer.
关键词	HEPATOCYTE GROWTH-FACTOR CANCER EPITHELIAL-CELLS PROGNOSTIC MARKER CHANNELS PROLIFERATION RECEPTOR TRPM8 PROGRESSION ENTRY TRPV6 benign prostatic hyperplasia immunohistochemistry prostate cancer TRPC6
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3679864
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/158196
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院地质与地球物理研究所
推荐引用方式 GB/T 7714	Yue Dan,Wang Yong,Xiao JianYing,et al. Expression of TRPC6 in benign and malignant human prostate tissues[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(5):541-547.
APA	Yue Dan,Wang Yong,Xiao JianYing,Wang Ping,&Ren ChangShan.(2009).Expression of TRPC6 in benign and malignant human prostate tissues.ASIAN JOURNAL OF ANDROLOGY,11(5),541-547.
MLA	Yue Dan,et al."Expression of TRPC6 in benign and malignant human prostate tissues".ASIAN JOURNAL OF ANDROLOGY 11.5(2009):541-547.