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Expression of TRPC6 in benign and malignant human prostate tissues
Alternative TitleExpression of TRPC6 in benign and malignant human prostate tissues
Yue Dan1; Wang Yong1; Xiao JianYing2; Wang Ping1; Ren ChangShan1
2009
Source PublicationASIAN JOURNAL OF ANDROLOGY
ISSN1008-682X
Volume11Issue:5Pages:541-547
AbstractWe investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. Immunohistochemical techniques, Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. TRPC6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (BPH) cases, and there was a significant difference compared with prostate cancer (129 of 149 86.6%) (P < 0.01). TRPC6 expression was associated with the histological grade and extraprostatic extension (P < 0.01). Tumors of higher stage tended to have a higher frequency of TRPC6 protein staining, but the difference was not significant among T2, T3 and T4. TRPC6 expression difference between androgen-independent (AI) tumors and androgen-dependent (AD) tumors was not statistically significant. TRPC6 was also observed in prostate cancer cell lines. In summary, TRPC6 is detected in benign and malignant human prostate tissues and prostate cancer cell lines and is associated with the histological grade, Gleason score and extraprostatic extension of prostate cancer.
Other AbstractWe investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. Immunohistochemical techniques, Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. TRPC6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (BPH) cases, and there was a significant difference compared with prostate cancer (129 of 149 86.6%)( P < 0.01). TRPC6 expression was associated with the histological grade and extraprostatic extension ( P < 0.01). Tumors of higher stage tended to have a higher frequency of TRPC6 protein staining, but the difference was not significant among T2, T3 and T4. TRPC6 expression difference between androgen-independent (AI) tumors and androgen-dependent (AD) tumors was not statistically significant. TRPC6 was also observed in prostate cancer cell lines. In summary, TRPC6 is detected in benign and malignant human prostate tissues and prostate cancer cell lines and is associated with the histological grade, Gleason score and extraprostatic extension of prostate cancer.
KeywordHEPATOCYTE GROWTH-FACTOR CANCER EPITHELIAL-CELLS PROGNOSTIC MARKER CHANNELS PROLIFERATION RECEPTOR TRPM8 PROGRESSION ENTRY TRPV6 benign prostatic hyperplasia immunohistochemistry prostate cancer TRPC6
Indexed ByCSCD
Language英语
CSCD IDCSCD:3679864
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158196
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.中国科学院地质与地球物理研究所
Recommended Citation
GB/T 7714
Yue Dan,Wang Yong,Xiao JianYing,et al. Expression of TRPC6 in benign and malignant human prostate tissues[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(5):541-547.
APA Yue Dan,Wang Yong,Xiao JianYing,Wang Ping,&Ren ChangShan.(2009).Expression of TRPC6 in benign and malignant human prostate tissues.ASIAN JOURNAL OF ANDROLOGY,11(5),541-547.
MLA Yue Dan,et al."Expression of TRPC6 in benign and malignant human prostate tissues".ASIAN JOURNAL OF ANDROLOGY 11.5(2009):541-547.
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