Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro

doi:10.1016/j.jmst.2020.05.030

IMR OpenIR

	Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro
	Li, Mingjun 1,2; Nan, Li 2; Liang, Chunyong 1; Sun, Ziqing 2; Yang, Lei 1,3; Yang, Ke 2
通讯作者	Yang, Lei(ylei@hebut.edu.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2021-01-30
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	62 页码:139-147
摘要	Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are the most typical pathogenic bacteria with a significantly high risk of bio-contamination, widely existing in hospital and public places. Recent studies on antibacterial materials and the related mechanisms have attracted more interests of researchers. However, the antibacterial behavior of materials is usually evaluated separately on the single bacterial strain, which is far from the practical condition. Actually, the interaction between the polymicrobial communities can promote the growing profile of bacteria, which may weaken the antibacterial effect of materials. In this work, a 420 copper-bearing martensitic stainless steel (420CuSS) was studied with respect to its antibacterial activity and the underlying mechanism in a co-culturing infection model using both E. coli and S. aureus. Observed via plating and counting colony forming units (CFU), Cu releasing, and material characterization, 420CuSS was proved to present excellent antibacterial performance against the mixed bacteria with an approximately 99.4 % of antibacterial rate. In addition, 420CuSS could effectively inhibit the biofilm formation on its surfaces, resulting from a synergistic antibacterial effect of Cu ions, Fe ions, reactive oxygen species (ROS), and proton consumption of bacteria. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Mixed bacterial strains E. coli S. aureus 420 Cu-bearing stainless steel Antibacterial mechanism
资助者	National Natural Science Foundation of China ; National Basic Research Program of China ; National Key R&D Program of China
DOI	10.1016/j.jmst.2020.05.030
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51101154] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[51672184] ; National Natural Science Foundation of China[51371168] ; National Basic Research Program of China[2012CB619101] ; National Key R&D Program of China[2020YFC1107400]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000601221700014
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/158830
专题	中国科学院金属研究所
通讯作者	Yang, Lei; Yang, Ke
作者单位	1.Hebei Univ Technol, Ctr Hlth Sci & Engn, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China 2.Univ Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Int Res Ctr Translat Orthopaed IRCTO, Suzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Mingjun,Nan, Li,Liang, Chunyong,et al. Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,62:139-147.
APA	Li, Mingjun,Nan, Li,Liang, Chunyong,Sun, Ziqing,Yang, Lei,&Yang, Ke.(2021).Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,62,139-147.
MLA	Li, Mingjun,et al."Antibacterial behavior and related mechanisms of martensitic Cu-bearing stainless steel evaluated by a mixed infection model of C Escherichia coli and Staphylococcus aureus in vitro".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 62(2021):139-147.