IMR OpenIR
In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction
Wu, Jingyao1; Mady, Leila J.2; Roy, Abhijit1; Aral, Ali Mubin3; Lee, Boeun1; Zheng, Feng4; Catalin, Toma5,6; Chun, Youngjae1,6,7; Wagner, William R.1,3,6,8; Yang, Ke; Trejo Bittar, Humberto E.9; Chi, David10; Kumta, Prashant N.1,6,8,11,12,13
Corresponding AuthorKumta, Prashant N.(pkumta@pitt.edu)
2020-12-18
Source PublicationCOMMUNICATIONS BIOLOGY
Volume3Issue:1Pages:11
AbstractPediatric laryngotracheal stenosis is a complex congenital or acquired airway injury that may manifest into a potentially life-threatening airway emergency condition. Depending on the severity of obstruction, treatment often requires a combination of endoscopic techniques, open surgical repair, intraluminal stenting, or tracheostomy. A balloon expandable biodegradable airway stent maintaining patency while safely degrading over time may address the complications and morbidity issues of existing treatments providing a less invasive and more effective management technique. Previous studies have focused on implementation of degradable polymeric scaffolds associated with potentially life-threatening pitfalls. The feasibility of an ultra-high ductility magnesium-alloy based biodegradable airway stents was demonstrated for the first time. The stents were highly corrosion resistant under in vitro flow environments, while safely degrading in vivo without affecting growth of the rabbit airway. The metallic matrix and degradation products were well tolerated by the airway tissue without exhibiting any noticeable local or systemic toxicity. Wu et al. demonstrate utility of a novel, ultrahigh ductility Mg alloy-based biodegradable stent in vitro and in vivo for use in congenital disorders like pediatric laryngotracheal stenosis. Tested in both bioreactor system and rabbit airway model, these stents display higher corrosion resistance and better in vivo degradation without affecting growth of rabbit airway.
Funding OrganizationNSF ; National Science Foundation ; Edward R. Weidlein Chair Professorship Funds ; Center for Complex Engineered Multifunctional Materials (CCEMM) at the Swanson School of Engineering in the University of Pittsburgh
DOI10.1038/s42003-020-01400-7
Indexed BySCI
Language英语
Funding ProjectNSF[EEC-0812348] ; National Science Foundation[CBET-0933153] ; Edward R. Weidlein Chair Professorship Funds ; Center for Complex Engineered Multifunctional Materials (CCEMM) at the Swanson School of Engineering in the University of Pittsburgh
WOS Research AreaLife Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS SubjectBiology ; Multidisciplinary Sciences
WOS IDWOS:000608502100002
PublisherNATURE RESEARCH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/158949
Collection中国科学院金属研究所
Corresponding AuthorKumta, Prashant N.
Affiliation1.Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA
2.Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15261 USA
3.Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA
4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
5.Univ Pittsburgh, Med Ctr, Heart & Vasc Inst, Pittsburgh, PA 15261 USA
6.McGowan Inst Regenerat Med, Pittsburgh, PA 15261 USA
7.Univ Pittsburgh, Dept Ind Engn, Pittsburgh, PA 15261 USA
8.Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15261 USA
9.Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
10.Childrens Hosp Pittsburgh UPMC, Dept Otolaryngol, Pittsburgh, PA 15224 USA
11.Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15261 USA
12.Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Pittsburgh, PA 15261 USA
13.Univ Pittsburgh, Ctr Complex Engn Multifunct Mat, Pittsburgh, PA 15261 USA
Recommended Citation
GB/T 7714
Wu, Jingyao,Mady, Leila J.,Roy, Abhijit,et al. In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction[J]. COMMUNICATIONS BIOLOGY,2020,3(1):11.
APA Wu, Jingyao.,Mady, Leila J..,Roy, Abhijit.,Aral, Ali Mubin.,Lee, Boeun.,...&Kumta, Prashant N..(2020).In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction.COMMUNICATIONS BIOLOGY,3(1),11.
MLA Wu, Jingyao,et al."In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction".COMMUNICATIONS BIOLOGY 3.1(2020):11.
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