Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine

doi:10.1016/j.jmst.2020.05.008

IMR OpenIR

	Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine
	Yuan, Xiaoxue 1,2; Liu, Ran 4; Zhang, Wenchang 1,2; Song, Xiaoqiang 1,2; Xu, Lei 1; Zhao, Yan 1; Shang, Lei 3; Zhang, Jingsong 1
通讯作者	Zhao, Yan(yanzhao@imr.ac.cn) ; Shang, Lei(shanglei6677@163.com) ; Zhang, Jingsong(jshzhang@imr.ac.cn)
	2021-02-10
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	63 页码:210-215
摘要	Controlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies, and it is important to predict and control the release kinetics to fully take advantage of this technology. Carboxylmethylchitosan (CMCS) and alginate (SA) blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere, which induced the protonation of the amino groups of CMCS, and the formation of polyelectrolyte composite hydrogels. By using diclofenac diethylamine as the model drug, the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment, which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the membrane. The study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Polyelectrolyte complex hydrogel Carboxymethyl chitosan Alginate Diffusion controlled release
资助者	National Natural Science Foundation of China
DOI	10.1016/j.jmst.2020.05.008
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U1608255]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000608708100022
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/159036
专题	中国科学院金属研究所
通讯作者	Zhao, Yan; Shang, Lei; Zhang, Jingsong
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 3.Shenyang Med Coll, Sch Pharm, Shenyang 110034, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiaoxue,Liu, Ran,Zhang, Wenchang,et al. Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,63:210-215.
APA	Yuan, Xiaoxue.,Liu, Ran.,Zhang, Wenchang.,Song, Xiaoqiang.,Xu, Lei.,...&Zhang, Jingsong.(2021).Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,63,210-215.
MLA	Yuan, Xiaoxue,et al."Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 63(2021):210-215.