IMR OpenIR
Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo
Hang, Xiaodong1; Liu, Xiaohan1; Hu, Ying2; Jiao, Yilai3; Wu, Lin1
Corresponding AuthorWu, Lin(wulin13@163.com)
2021-07-30
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Volume2021Pages:7
AbstractThe aim of this study was to evaluate the biocompatibility and osteogenic potential of a Zeolite Socony Mobil-5 (ZSM-5) coating on a Ti-24 Nb-4 Zr-7.9 Sn (Ti-2448) surface. ZSM-5-modified Ti-2448 (ZSM-5/Ti-2448) and Ti-2448 (control) groups were employed. The physical and chemical properties of the two types of samples were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption/desorption, and contact angle methods. The surface of the ZSM-5/Ti-2448 was rougher than that of the original Ti-2448, while the contact angle of the ZSM-5/Ti-2448 was smaller than that of Ti-2448. In addition, the ZSM-5/Ti-2448 largely increased the specific surface area and introduced silanol groups. A bone-like apatite layer could be formed on the surface of ZSM-5/Ti-2448 after 14 days of incubation in a simulated body fluid. ZSM-5/Ti-2448 was not cytotoxic. The number and alkaline phosphatase (ALP) activity of osteoblasts on ZSM-5/Ti-2448 were significantly higher than those on Ti-2448 surfaces, obtained in vitro using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide and ALP activity assays. Few inflammatory cells were observed around ZSM-5/Ti-2448 after insertion into the femurs of Japanese white rabbits after 4, 12, and 26 weeks through hematoxylin-eosin staining. The average gray scale of transforming growth factor-beta 1 (TGF-beta 1) on ZSM-5/Ti-2448 peaked earlier than that on Ti-2448, according to immunohistochemical staining. These results indicate that ZSM-5/Ti-2448 has a good biocompatibility and improved early osteogenic potential compared to a noncoated Ti-2448.
Funding OrganizationNational High-Tech Research and Development Program (863 Program) of China
DOI10.1155/2021/5529368
Indexed BySCI
Language英语
Funding ProjectNational High-Tech Research and Development Program (863 Program) of China[2015AA033702]
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000684340400006
PublisherHINDAWI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/159338
Collection中国科学院金属研究所
Corresponding AuthorWu, Lin
Affiliation1.China Med Univ, Liaoning Prov Key Lab Oral Dis, Dept Prosthodont, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China
2.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian, Peoples R China
3.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang, Peoples R China
Recommended Citation
GB/T 7714
Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,et al. Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:7.
APA Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,Jiao, Yilai,&Wu, Lin.(2021).Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo.BIOMED RESEARCH INTERNATIONAL,2021,7.
MLA Hang, Xiaodong,et al."Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo".BIOMED RESEARCH INTERNATIONAL 2021(2021):7.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hang, Xiaodong]'s Articles
[Liu, Xiaohan]'s Articles
[Hu, Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hang, Xiaodong]'s Articles
[Liu, Xiaohan]'s Articles
[Hu, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hang, Xiaodong]'s Articles
[Liu, Xiaohan]'s Articles
[Hu, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.