Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo

doi:10.1155/2021/5529368

IMR OpenIR

	Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo
	Hang, Xiaodong 1; Liu, Xiaohan 1; Hu, Ying 2; Jiao, Yilai 3; Wu, Lin 1
通讯作者	Wu, Lin(wulin13@163.com)
	2021-07-30
发表期刊	BIOMED RESEARCH INTERNATIONAL
ISSN	2314-6133
卷号	2021 页码:7
摘要	The aim of this study was to evaluate the biocompatibility and osteogenic potential of a Zeolite Socony Mobil-5 (ZSM-5) coating on a Ti-24 Nb-4 Zr-7.9 Sn (Ti-2448) surface. ZSM-5-modified Ti-2448 (ZSM-5/Ti-2448) and Ti-2448 (control) groups were employed. The physical and chemical properties of the two types of samples were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption/desorption, and contact angle methods. The surface of the ZSM-5/Ti-2448 was rougher than that of the original Ti-2448, while the contact angle of the ZSM-5/Ti-2448 was smaller than that of Ti-2448. In addition, the ZSM-5/Ti-2448 largely increased the specific surface area and introduced silanol groups. A bone-like apatite layer could be formed on the surface of ZSM-5/Ti-2448 after 14 days of incubation in a simulated body fluid. ZSM-5/Ti-2448 was not cytotoxic. The number and alkaline phosphatase (ALP) activity of osteoblasts on ZSM-5/Ti-2448 were significantly higher than those on Ti-2448 surfaces, obtained in vitro using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide and ALP activity assays. Few inflammatory cells were observed around ZSM-5/Ti-2448 after insertion into the femurs of Japanese white rabbits after 4, 12, and 26 weeks through hematoxylin-eosin staining. The average gray scale of transforming growth factor-beta 1 (TGF-beta 1) on ZSM-5/Ti-2448 peaked earlier than that on Ti-2448, according to immunohistochemical staining. These results indicate that ZSM-5/Ti-2448 has a good biocompatibility and improved early osteogenic potential compared to a noncoated Ti-2448.
资助者	National High-Tech Research and Development Program (863 Program) of China
DOI	10.1155/2021/5529368
收录类别	SCI
语种	英语
资助项目	National High-Tech Research and Development Program (863 Program) of China[2015AA033702]
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号	WOS:000684340400006
出版者	HINDAWI LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/159338
专题	中国科学院金属研究所
通讯作者	Wu, Lin
作者单位	1.China Med Univ, Liaoning Prov Key Lab Oral Dis, Dept Prosthodont, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China 2.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian, Peoples R China 3.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang, Peoples R China
推荐引用方式 GB/T 7714	Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,et al. Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:7.
APA	Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,Jiao, Yilai,&Wu, Lin.(2021).Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo.BIOMED RESEARCH INTERNATIONAL,2021,7.
MLA	Hang, Xiaodong,et al."Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo".BIOMED RESEARCH INTERNATIONAL 2021(2021):7.