| Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation | |
| Chen, Shi-ting1; He, Si-yuan1; Wang, Wan-ying2; Jin, Hai-jun3; Lu, Jian4; Zhang, Ye-yuan3 | |
| 通讯作者 | He, Si-yuan(hesiyuan@gmail.com) |
| 2021-10-15 | |
| 发表期刊 | MATERIALS LETTERS
 |
| ISSN | 0167-577X |
| 卷号 | 301页码:3 |
| 摘要 | Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation. |
| 关键词 | Nanoporous gold Dealloying Cell encapsulation Diabetes treatment Biomaterials Porous material |
| 资助者 | National Natural ScienceFoundation of China |
| DOI | 10.1016/j.matlet.2021.130224 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural ScienceFoundation of China[52071057] ; National Natural ScienceFoundation of China[11572087] |
| WOS研究方向 | Materials Science ; Physics |
| WOS类目 | Materials Science, Multidisciplinary ; Physics, Applied |
| WOS记录号 | WOS:000675889300005 |
| 出版者 | ELSEVIER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/159813 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | He, Si-yuan |
| 作者单位 | 1.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China 2.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 4.City Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,et al. Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation[J]. MATERIALS LETTERS,2021,301:3. |
| APA | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,Jin, Hai-jun,Lu, Jian,&Zhang, Ye-yuan.(2021).Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation.MATERIALS LETTERS,301,3. |
| MLA | Chen, Shi-ting,et al."Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation".MATERIALS LETTERS 301(2021):3. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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