| Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation | |
| Chen, Shi-ting1; He, Si-yuan1; Wang, Wan-ying2; Jin, Hai-jun3; Lu, Jian4; Zhang, Ye-yuan3 | |
| Corresponding Author | He, Si-yuan(hesiyuan@gmail.com) |
| 2021-10-15 | |
| Source Publication | MATERIALS LETTERS
 |
| ISSN | 0167-577X |
| Volume | 301Pages:3 |
| Abstract | Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation. |
| Keyword | Nanoporous gold Dealloying Cell encapsulation Diabetes treatment Biomaterials Porous material |
| Funding Organization | National Natural ScienceFoundation of China |
| DOI | 10.1016/j.matlet.2021.130224 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural ScienceFoundation of China[52071057] ; National Natural ScienceFoundation of China[11572087] |
| WOS Research Area | Materials Science ; Physics |
| WOS Subject | Materials Science, Multidisciplinary ; Physics, Applied |
| WOS ID | WOS:000675889300005 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/159813 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | He, Si-yuan |
| Affiliation | 1.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China 2.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 4.City Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,et al. Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation[J]. MATERIALS LETTERS,2021,301:3. |
| APA | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,Jin, Hai-jun,Lu, Jian,&Zhang, Ye-yuan.(2021).Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation.MATERIALS LETTERS,301,3. |
| MLA | Chen, Shi-ting,et al."Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation".MATERIALS LETTERS 301(2021):3. |
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