Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo

doi:10.1002/jbm.b.34907

IMR OpenIR

	Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo
	Erisen, Deniz Eren 1,2; Zhang, Yuqi 3; Zhang, Bingchun 2; Yang, Ke 2; Chen, Shanshan 2; Wang, Xiaolin 3
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Chen, Shanshan(sschen@imr.ac.cn) ; Wang, Xiaolin(wangxl80@126.com.cn)
	2021-07-08
发表期刊	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN	1552-4973
页码	10
摘要	Biosafety of AZ31B magnesium (Mg) alloy and the effect of its degradation products on tissues, organs, and whole systems are highly needed to be evaluated before clinical application. This study serves a wide variety of safety evaluations of biodegradable AZ31B alloy on nerve cells. As a result of this in vitro study, the maximum aluminum (Al) ion and Mg ion concentrations in the medium were estimated to be 22 mu mol/L and 2.75 mmol/L, respectively, during degradation. In addition, the corresponding cell mortality was observed to be 36% and lower than 5% according to the resistance curves of the cell to Mg and Al ions. Furthermore, the maximum Al ion and Mg ion concentrations in serum and cerebrospinal fluid were detected to be 26.1 mu mol/L and 1.2 mmol/L, respectively, for 5 months implantation. Combining the result of in vivo dialysis with the result of ion tolerance assay experiments, the actual death rate of nerve cells is estimated between 4 and 10% in vivo, which is lower than the result of in vitro cytotoxicity evaluation. Moreover, no psychomotor disability during clinical studies is observed. Consequently, stent made of AZ31B alloy with surface treatment is feasible for carotid artery stenosis, and it is safe in terms of cell viability on the nervous system.
关键词	biodegradable cytotoxicity magnesium alloy metal ions vascular stents
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China
DOI	10.1002/jbm.b.34907
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC1102404] ; National Natural Science Foundation of China[51901227]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000670600400001
出版者	WILEY
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/160013
专题	中国科学院金属研究所
通讯作者	Yang, Ke; Chen, Shanshan; Wang, Xiaolin
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 3.Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Erisen, Deniz Eren,Zhang, Yuqi,Zhang, Bingchun,et al. Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2021:10.
APA	Erisen, Deniz Eren,Zhang, Yuqi,Zhang, Bingchun,Yang, Ke,Chen, Shanshan,&Wang, Xiaolin.(2021).Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,10.
MLA	Erisen, Deniz Eren,et al."Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021):10.