IMR OpenIR
One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing
Wan, Peng1,2; Wang, Weidan3; Zheng, Lizhen2; Qin, Ling2; Yang, Ke4
Corresponding AuthorWan, Peng(wanpeng@dgut.edu.cn) ; Qin, Ling(qin@ort.cuhk.edu.hk)
2021-07-10
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume78Pages:92-99
AbstractOsteoporotic fracture with increase of aging population became an urgent orthopedic problem. Bisphosphonates were widely recommended as effective clinical treatment drugs. Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing. Considering the mild and sustained drug release, a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study. In comparison to conventional soaking method, encapsulated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled manner. The in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts, which could improve bone-forming and decrease bone resorption due to osteoporosis. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
KeywordBisphosphonate Magnesium Coating Electrodeposition Osteoporosis
Funding OrganizationNational Natural Science Foundation of China ; Research start-up funds of DGUT ; Scientific Research Foundation for Young Team of DGUT
DOI10.1016/j.jmst.2020.10.055
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31500777] ; Research start-up funds of DGUT[GC300501-082] ; Scientific Research Foundation for Young Team of DGUT[TDQN2019005]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000652023600009
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/161500
Collection中国科学院金属研究所
Corresponding AuthorWan, Peng; Qin, Ling
Affiliation1.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Peoples R China
2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China
3.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Wan, Peng,Wang, Weidan,Zheng, Lizhen,et al. One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,78:92-99.
APA Wan, Peng,Wang, Weidan,Zheng, Lizhen,Qin, Ling,&Yang, Ke.(2021).One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,78,92-99.
MLA Wan, Peng,et al."One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 78(2021):92-99.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wan, Peng]'s Articles
[Wang, Weidan]'s Articles
[Zheng, Lizhen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wan, Peng]'s Articles
[Wang, Weidan]'s Articles
[Zheng, Lizhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wan, Peng]'s Articles
[Wang, Weidan]'s Articles
[Zheng, Lizhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.