One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing

doi:10.1016/j.jmst.2020.10.055

IMR OpenIR

	One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing
	Wan, Peng 1,2; Wang, Weidan 3; Zheng, Lizhen 2; Qin, Ling 2; Yang, Ke 4
通讯作者	Wan, Peng(wanpeng@dgut.edu.cn) ; Qin, Ling(qin@ort.cuhk.edu.hk)
	2021-07-10
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	78 页码:92-99
摘要	Osteoporotic fracture with increase of aging population became an urgent orthopedic problem. Bisphosphonates were widely recommended as effective clinical treatment drugs. Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing. Considering the mild and sustained drug release, a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study. In comparison to conventional soaking method, encapsulated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled manner. The in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts, which could improve bone-forming and decrease bone resorption due to osteoporosis. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Bisphosphonate Magnesium Coating Electrodeposition Osteoporosis
资助者	National Natural Science Foundation of China ; Research start-up funds of DGUT ; Scientific Research Foundation for Young Team of DGUT
DOI	10.1016/j.jmst.2020.10.055
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31500777] ; Research start-up funds of DGUT[GC300501-082] ; Scientific Research Foundation for Young Team of DGUT[TDQN2019005]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000652023600009
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/161500
专题	中国科学院金属研究所
通讯作者	Wan, Peng; Qin, Ling
作者单位	1.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Peoples R China 2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China 3.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Wan, Peng,Wang, Weidan,Zheng, Lizhen,et al. One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,78:92-99.
APA	Wan, Peng,Wang, Weidan,Zheng, Lizhen,Qin, Ling,&Yang, Ke.(2021).One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,78,92-99.
MLA	Wan, Peng,et al."One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 78(2021):92-99.