| Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges | |
| Song, Xiaoqiang1,2; Zhao, Yan1; Liu, Yunen3; Zhang, Wenchang1; Yuan, Xiaoxue1,2; Xu, Lei1; Zhang, Jinsong1 | |
| Corresponding Author | Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jszhang@imr.ac.cn) |
| 2021-12-01 | |
| Source Publication | CARBOHYDRATE POLYMERS
 |
| ISSN | 0144-8617 |
| Volume | 273Pages:10 |
| Abstract | Chitin/chitosan hemostatic materials have long been studied for uncontrolled hemorrhage, an urgent clinical problem due to severe blood-vessel damage or hemophilia. As one of the basic structural parameters of chitin, the degree of deacetylation (DD) significantly affects the material's physical, chemical, as well as biological properties. In this study, partially deacetylated chitins with a wide range of DD (23-81%) were prepared by homogeneous deacetylation, and sponges with these various chitins were fabricated by freeze-drying to study the effects of DD on their hemostatic properties. Among all sponge samples, the chitosan sponge with a DD of 48% showed the highest water absorption, whole blood adsorption, RBC adsorption rate, and the best hemostatic performance in an uncontrolled bleeding model of the rat femoral artery, demonstrating that a certain proportion of acetyl amino and amino groups could also activate the coagulation system and promote the adhesion of platelet and erythrocyte. |
| Keyword | Chitin Homogeneous deacetylation Sponge Degree of deacetylation Femoral artery hemostasis |
| Funding Organization | National Key Research and Devel-opment Plan ; National Natural ScienceFoundation of China |
| DOI | 10.1016/j.carbpol.2021.118615 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Devel-opment Plan[2016YFB0301502] ; National Natural ScienceFoundation of China[U1608255] |
| WOS Research Area | Chemistry ; Polymer Science |
| WOS Subject | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS ID | WOS:000704379800008 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/166544 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhao, Yan; Zhang, Jinsong |
| Affiliation | 1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Gen Hosp Northern Theater Command, Dept Emergency Med, Shenyang 110016, PR, Peoples R China |
| Recommended Citation GB/T 7714 | Song, Xiaoqiang,Zhao, Yan,Liu, Yunen,et al. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges[J]. CARBOHYDRATE POLYMERS,2021,273:10. |
| APA | Song, Xiaoqiang.,Zhao, Yan.,Liu, Yunen.,Zhang, Wenchang.,Yuan, Xiaoxue.,...&Zhang, Jinsong.(2021).Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges.CARBOHYDRATE POLYMERS,273,10. |
| MLA | Song, Xiaoqiang,et al."Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges".CARBOHYDRATE POLYMERS 273(2021):10. |
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