IMR OpenIR
Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges
Song, Xiaoqiang1,2; Zhao, Yan1; Liu, Yunen3; Zhang, Wenchang1; Yuan, Xiaoxue1,2; Xu, Lei1; Zhang, Jinsong1
Corresponding AuthorZhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jszhang@imr.ac.cn)
2021-12-01
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume273Pages:10
AbstractChitin/chitosan hemostatic materials have long been studied for uncontrolled hemorrhage, an urgent clinical problem due to severe blood-vessel damage or hemophilia. As one of the basic structural parameters of chitin, the degree of deacetylation (DD) significantly affects the material's physical, chemical, as well as biological properties. In this study, partially deacetylated chitins with a wide range of DD (23-81%) were prepared by homogeneous deacetylation, and sponges with these various chitins were fabricated by freeze-drying to study the effects of DD on their hemostatic properties. Among all sponge samples, the chitosan sponge with a DD of 48% showed the highest water absorption, whole blood adsorption, RBC adsorption rate, and the best hemostatic performance in an uncontrolled bleeding model of the rat femoral artery, demonstrating that a certain proportion of acetyl amino and amino groups could also activate the coagulation system and promote the adhesion of platelet and erythrocyte.
KeywordChitin Homogeneous deacetylation Sponge Degree of deacetylation Femoral artery hemostasis
Funding OrganizationNational Key Research and Devel-opment Plan ; National Natural ScienceFoundation of China
DOI10.1016/j.carbpol.2021.118615
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Devel-opment Plan[2016YFB0301502] ; National Natural ScienceFoundation of China[U1608255]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000704379800008
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/166544
Collection中国科学院金属研究所
Corresponding AuthorZhao, Yan; Zhang, Jinsong
Affiliation1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
3.Gen Hosp Northern Theater Command, Dept Emergency Med, Shenyang 110016, PR, Peoples R China
Recommended Citation
GB/T 7714
Song, Xiaoqiang,Zhao, Yan,Liu, Yunen,et al. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges[J]. CARBOHYDRATE POLYMERS,2021,273:10.
APA Song, Xiaoqiang.,Zhao, Yan.,Liu, Yunen.,Zhang, Wenchang.,Yuan, Xiaoxue.,...&Zhang, Jinsong.(2021).Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges.CARBOHYDRATE POLYMERS,273,10.
MLA Song, Xiaoqiang,et al."Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges".CARBOHYDRATE POLYMERS 273(2021):10.
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