Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges

doi:10.1016/j.carbpol.2021.118615

IMR OpenIR

	Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges
	Song, Xiaoqiang 1,2; Zhao, Yan 1; Liu, Yunen 3; Zhang, Wenchang 1; Yuan, Xiaoxue 1,2; Xu, Lei 1; Zhang, Jinsong 1
通讯作者	Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jszhang@imr.ac.cn)
	2021-12-01
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	273 页码:10
摘要	Chitin/chitosan hemostatic materials have long been studied for uncontrolled hemorrhage, an urgent clinical problem due to severe blood-vessel damage or hemophilia. As one of the basic structural parameters of chitin, the degree of deacetylation (DD) significantly affects the material's physical, chemical, as well as biological properties. In this study, partially deacetylated chitins with a wide range of DD (23-81%) were prepared by homogeneous deacetylation, and sponges with these various chitins were fabricated by freeze-drying to study the effects of DD on their hemostatic properties. Among all sponge samples, the chitosan sponge with a DD of 48% showed the highest water absorption, whole blood adsorption, RBC adsorption rate, and the best hemostatic performance in an uncontrolled bleeding model of the rat femoral artery, demonstrating that a certain proportion of acetyl amino and amino groups could also activate the coagulation system and promote the adhesion of platelet and erythrocyte.
关键词	Chitin Homogeneous deacetylation Sponge Degree of deacetylation Femoral artery hemostasis
资助者	National Key Research and Devel-opment Plan ; National Natural ScienceFoundation of China
DOI	10.1016/j.carbpol.2021.118615
收录类别	SCI
语种	英语
资助项目	National Key Research and Devel-opment Plan[2016YFB0301502] ; National Natural ScienceFoundation of China[U1608255]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000704379800008
出版者	ELSEVIER SCI LTD
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/166544
专题	中国科学院金属研究所
通讯作者	Zhao, Yan; Zhang, Jinsong
作者单位	1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Gen Hosp Northern Theater Command, Dept Emergency Med, Shenyang 110016, PR, Peoples R China
推荐引用方式 GB/T 7714	Song, Xiaoqiang,Zhao, Yan,Liu, Yunen,et al. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges[J]. CARBOHYDRATE POLYMERS,2021,273:10.
APA	Song, Xiaoqiang.,Zhao, Yan.,Liu, Yunen.,Zhang, Wenchang.,Yuan, Xiaoxue.,...&Zhang, Jinsong.(2021).Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges.CARBOHYDRATE POLYMERS,273,10.
MLA	Song, Xiaoqiang,et al."Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges".CARBOHYDRATE POLYMERS 273(2021):10.