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Enhanced spreading, migration and osteodifferentiation of HBMSCs on macroporous CS-Ta-A biocompatible macroporous coating for hard tissue repair
Tang, Junrong1,2; Li, Hongyu3; Guo, Mingxiao1,2; Zhao, Zhipo1; Liu, Hanhui1,2; Ren, Yupeng1,2; Wang, Jiqiang1; Cui, Xinyu1; Shen, Yanfang1; Jin, Huazi1; Zhao, Ying3; Xiong, Tianying1
Corresponding AuthorZhao, Ying(ying.zhao@siat.ac.cn) ; Xiong, Tianying(tyxiong@imr.ac.cn)
2021-10-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume129Pages:12
AbstractMacroporous tantalum (Ta) coating was produced on titanium alloy implant for bone repair by cold spray (CS) technology, which is a promising technology for oxygen sensitive materials. The surface characteristics as well as in vitro cytocompatibility were systematically evaluated. The results showed that a rough and macroporous CS-Ta coating was formed on the Ti6Al4V (TC4) alloy surfaces. The surface roughness showed a significant enhancement from 17.06 mu m (CS-Ta-S), 27.48 mu m (CS-Ta-M) to 39.21 mu m (CS-Ta-L) with the increase of the average pore diameter of CS-Ta coatings from 138.25 mu m, 198.25 mu m to 355.56 mu m. In vitro results showed that macroporous CS-Ta structure with tantalum pentoxide (Ta2O5) was more favorable to induce human bone marrow derived mesenchymal stem cells (HBMSCs) spreading, migration and osteodifferentiation than TC4. Compared with the micro-scaled structure outside the macropores, the surface micro-nano structure inside the macropores was more favorable to promote osteodifferentiation with enhanced alkaline phosphatase (ALP) activity and extracellular matrix (ECM) mineralization. In particular, CS-Ta-L with the largest pore size showed significantly enhanced integrin-alpha 5 expression, cell migration, ALP activity, ECM mineralization as well as osteogenic-related genes including ALP, osteopontin (OPN) and osteocalcin (OCN) expression. Our results indicated that macroporous Ta coatings by CS, especially CS-Ta-L, may be promising for hard tissue repairs.
KeywordCold spray Ta coating Macroporous structure Micro-nano structure Osteodifferentiation Cell migration
Funding OrganizationNational Natural Science Foundation of China
DOI10.1016/j.msec.2021.112411
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81572113]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000703870800001
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/166717
Collection中国科学院金属研究所
Corresponding AuthorZhao, Ying; Xiong, Tianying
Affiliation1.Chinese Acad Sci, Inst Met Res, Shichangxu Innovat Ctr Adv Mat, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
Recommended Citation
GB/T 7714
Tang, Junrong,Li, Hongyu,Guo, Mingxiao,et al. Enhanced spreading, migration and osteodifferentiation of HBMSCs on macroporous CS-Ta-A biocompatible macroporous coating for hard tissue repair[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2021,129:12.
APA Tang, Junrong.,Li, Hongyu.,Guo, Mingxiao.,Zhao, Zhipo.,Liu, Hanhui.,...&Xiong, Tianying.(2021).Enhanced spreading, migration and osteodifferentiation of HBMSCs on macroporous CS-Ta-A biocompatible macroporous coating for hard tissue repair.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,129,12.
MLA Tang, Junrong,et al."Enhanced spreading, migration and osteodifferentiation of HBMSCs on macroporous CS-Ta-A biocompatible macroporous coating for hard tissue repair".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 129(2021):12.
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