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3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma
Cai, Bianyun1,2,3; Huang, Leizhen1,2; Wang, Jingcheng1,2; Sun, Dan4; Zhu, Ce1,2; Huang, Yong1,2; Li, Shujun5; Guo, Zhijun6; Liu, Limin1,2; Feng, Ganjun1,2; Li, Yubao1,2; Zhang, Li1,2
Corresponding AuthorFeng, Ganjun(gjfenghx@163.com) ; Li, Yubao(nic7504@scu.edu.cn) ; Zhang, Li(nic1976@scu.edu.cn)
2021-10-20
Source PublicationBIOCONJUGATE CHEMISTRY
ISSN1043-1802
Volume32Issue:10Pages:2184-2194
AbstractOsteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV-vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; National Science Foundation of Jiangsu Province
DOI10.1021/acs.bioconjchem.1c00367
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFA0201703] ; National Natural Science Foundation of China[52001324] ; National Natural Science Foundation of China[81772397] ; National Natural Science Foundation of China[82072434] ; National Science Foundation of Jiangsu Province[BK20200643]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS IDWOS:000710929100008
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/167098
Collection中国科学院金属研究所
Corresponding AuthorFeng, Ganjun; Li, Yubao; Zhang, Li
Affiliation1.Sichuan Univ, West China Hosp, Analyt & Testing Ctr, Dept Orthoped Surg, Chengdu 610065, Peoples R China
2.Sichuan Univ, West China Hosp, Orthoped Res Inst, Chengdu 610065, Peoples R China
3.Henan Univ Sci & Technol, Coll Med Technol & Engn, Luoyang 471023, Peoples R China
4.Queens Univ Belfast, Sch Mech & Aerosp Engn, Adv Composite Res Grp ACRG, Belfast BT9 5AH, Antrim, North Ireland
5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
6.China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Cai, Bianyun,Huang, Leizhen,Wang, Jingcheng,et al. 3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma[J]. BIOCONJUGATE CHEMISTRY,2021,32(10):2184-2194.
APA Cai, Bianyun.,Huang, Leizhen.,Wang, Jingcheng.,Sun, Dan.,Zhu, Ce.,...&Zhang, Li.(2021).3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.BIOCONJUGATE CHEMISTRY,32(10),2184-2194.
MLA Cai, Bianyun,et al."3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma".BIOCONJUGATE CHEMISTRY 32.10(2021):2184-2194.
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