3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma

doi:10.1021/acs.bioconjchem.1c00367

IMR OpenIR

	3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma
	Cai, Bianyun 1,2,3; Huang, Leizhen 1,2; Wang, Jingcheng 1,2; Sun, Dan 4; Zhu, Ce 1,2; Huang, Yong 1,2; Li, Shujun 5; Guo, Zhijun 6; Liu, Limin 1,2; Feng, Ganjun 1,2; Li, Yubao 1,2; Zhang, Li 1,2
通讯作者	Feng, Ganjun(gjfenghx@163.com) ; Li, Yubao(nic7504@scu.edu.cn) ; Zhang, Li(nic1976@scu.edu.cn)
	2021-10-20
发表期刊	BIOCONJUGATE CHEMISTRY
ISSN	1043-1802
卷号	32 期号:10 页码:2184-2194
摘要	Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV-vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Science Foundation of Jiangsu Province
DOI	10.1021/acs.bioconjchem.1c00367
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFA0201703] ; National Natural Science Foundation of China[52001324] ; National Natural Science Foundation of China[81772397] ; National Natural Science Foundation of China[82072434] ; National Science Foundation of Jiangsu Province[BK20200643]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS记录号	WOS:000710929100008
出版者	AMER CHEMICAL SOC
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/167098
专题	中国科学院金属研究所
通讯作者	Feng, Ganjun; Li, Yubao; Zhang, Li
作者单位	1.Sichuan Univ, West China Hosp, Analyt & Testing Ctr, Dept Orthoped Surg, Chengdu 610065, Peoples R China 2.Sichuan Univ, West China Hosp, Orthoped Res Inst, Chengdu 610065, Peoples R China 3.Henan Univ Sci & Technol, Coll Med Technol & Engn, Luoyang 471023, Peoples R China 4.Queens Univ Belfast, Sch Mech & Aerosp Engn, Adv Composite Res Grp ACRG, Belfast BT9 5AH, Antrim, North Ireland 5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 6.China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Cai, Bianyun,Huang, Leizhen,Wang, Jingcheng,et al. 3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma[J]. BIOCONJUGATE CHEMISTRY,2021,32(10):2184-2194.
APA	Cai, Bianyun.,Huang, Leizhen.,Wang, Jingcheng.,Sun, Dan.,Zhu, Ce.,...&Zhang, Li.(2021).3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.BIOCONJUGATE CHEMISTRY,32(10),2184-2194.
MLA	Cai, Bianyun,et al."3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma".BIOCONJUGATE CHEMISTRY 32.10(2021):2184-2194.