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In Vitro Study on the Piezodynamic Therapy with a BaTiO3-Coating Titanium Scaffold under Low-Intensity Pulsed Ultrasound Stimulation
Chen, Jie1,2; Li, Shujun3; Jiao, Yilai3; Li, Jidong1,2; Li, Yubao1,2; Hao, Yu-Lin3; Zuo, Yi1,2
Corresponding AuthorZuo, Yi(zoae@scu.edu.cn)
2021-10-20
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume13Issue:41Pages:49542-49555
AbstractTo solve the poor sustainability of electroactive stimulation in clinical therapy, a strategy of combining a piezoelectric BaTiO3-coated Ti6Al4V scaffold and lowintensity pulsed ultrasound (LIPUS) was unveiled and named here as piezodynamic therapy. Thus, cell behavior could be regulated phenomenally by force and electricity simultaneously. First, BaTiO3 was deposited uniformly on the surface of the threedimensional (3D) printed porous Ti6Al4V scaffold, which endowed the scaffold with excellent force-electricity responsiveness under pulsed ultrasound exposure. The results of live/dead staining, cell scanning electron microscopy, and F-actin staining showed that cells had better viability, better pseudo-foot adhesion, and more muscular actin bundles when they underwent the piezodynamic effect of ultrasound and piezoelectric coating. This piezodynamic therapy activated more mitochondria at the initial stage that intervened in the cell cycle by promoting cells' proliferation and weakened the apoptotic damage. The quantitative real-time polymerase chain reaction data further confirmed that the costimulation of the ultrasound and the piezoelectric scaffolds could trigger adequate current to upregulated the expression of osteogenic-related genes. The continuous electric cues could be generated by the BaTiO3-coated scaffold and intermittent LIPUS stimulation; thereon, more efficient bone healing would be promoted by piezodynamic therapy in future treatment.
Keywordpiezodynamic therapy Ti6Al4V scaffolds piezoelectric BaTiO3 coating LIPUS stimulation continuously electroactive on cells
Funding OrganizationSichuan International Science and Technology Innovation Cooperation Project ; Key Research Program of Frontier Sciences, CAS ; Fundamental Research Funds for the Central Universities
DOI10.1021/acsami.1c15611
Indexed BySCI
Language英语
Funding ProjectSichuan International Science and Technology Innovation Cooperation Project[2021YFH0122] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-JSC03102] ; Fundamental Research Funds for the Central Universities
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000710924900118
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/167290
Collection中国科学院金属研究所
Corresponding AuthorZuo, Yi
Affiliation1.Sichuan Univ, Res Ctr Nano Biomat, Chengdu 610064, Peoples R China
2.Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
3.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jie,Li, Shujun,Jiao, Yilai,et al. In Vitro Study on the Piezodynamic Therapy with a BaTiO3-Coating Titanium Scaffold under Low-Intensity Pulsed Ultrasound Stimulation[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(41):49542-49555.
APA Chen, Jie.,Li, Shujun.,Jiao, Yilai.,Li, Jidong.,Li, Yubao.,...&Zuo, Yi.(2021).In Vitro Study on the Piezodynamic Therapy with a BaTiO3-Coating Titanium Scaffold under Low-Intensity Pulsed Ultrasound Stimulation.ACS APPLIED MATERIALS & INTERFACES,13(41),49542-49555.
MLA Chen, Jie,et al."In Vitro Study on the Piezodynamic Therapy with a BaTiO3-Coating Titanium Scaffold under Low-Intensity Pulsed Ultrasound Stimulation".ACS APPLIED MATERIALS & INTERFACES 13.41(2021):49542-49555.
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