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Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology
Liu, Hui1,2; Tang, Yulong3; Zhang, Shuyuan2; Liu, Huan1,2; Wang, Zijian3; Li, Yue3; Wang, Xinluan4,5,6; Ren, Ling2; Yang, Ke2; Qin, Ling4,5,6
Corresponding AuthorRen, Ling(lren@imr.ac.cn) ; Yang, Ke(Kyang@imr.ac.cn) ; Qin, Ling(lingqin@cuhk.edu.hk)
2022-02-01
Source PublicationBIOACTIVE MATERIALS
Volume8Pages:381-395
AbstractThis work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.
KeywordTitanium-copper alloy implants Anti-infection Oral microbiology Biosafety
Funding OrganizationBureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; Natural Science Foundation of China ; Liaoning Revitalization Talents Program
DOI10.1016/j.bioactmat.2021.05.053
Indexed BySCI
Language英语
Funding ProjectBureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; Natural Science Foundation of China[51631009] ; Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000751867500027
PublisherKEAI PUBLISHING LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/173429
Collection中国科学院金属研究所
Corresponding AuthorRen, Ling; Yang, Ke; Qin, Ling
Affiliation1.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China
2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
3.Gen Hosp Northern Mil Area, Dept Stomatol, 83 Wenhua Rd, Shenyang 110016, Peoples R China
4.Chinese Acad Sci, Translat Med R&D Ctr, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518057, Peoples R China
5.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China
6.Chinese Univ Hong Kong, Innovat Orthopaed Biomat & Drug Translat Res Lab, Li Ka Shing Inst Hlth, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Hui,Tang, Yulong,Zhang, Shuyuan,et al. Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology[J]. BIOACTIVE MATERIALS,2022,8:381-395.
APA Liu, Hui.,Tang, Yulong.,Zhang, Shuyuan.,Liu, Huan.,Wang, Zijian.,...&Qin, Ling.(2022).Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology.BIOACTIVE MATERIALS,8,381-395.
MLA Liu, Hui,et al."Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology".BIOACTIVE MATERIALS 8(2022):381-395.
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