Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology

doi:10.1016/j.bioactmat.2021.05.053

IMR OpenIR

	Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology
	Liu, Hui 1,2; Tang, Yulong 3; Zhang, Shuyuan 2; Liu, Huan 1,2; Wang, Zijian 3; Li, Yue 3; Wang, Xinluan 4,5,6; Ren, Ling 2; Yang, Ke 2; Qin, Ling 4,5,6
通讯作者	Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(Kyang@imr.ac.cn) ; Qin, Ling(lingqin@cuhk.edu.hk)
	2022-02-01
发表期刊	BIOACTIVE MATERIALS
卷号	8 页码:381-395
摘要	This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.
关键词	Titanium-copper alloy implants Anti-infection Oral microbiology Biosafety
资助者	Bureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; Natural Science Foundation of China ; Liaoning Revitalization Talents Program
DOI	10.1016/j.bioactmat.2021.05.053
收录类别	SCI
语种	英语
资助项目	Bureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; Natural Science Foundation of China[51631009] ; Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000751867500027
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/173429
专题	中国科学院金属研究所
通讯作者	Ren, Ling; Yang, Ke; Qin, Ling
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Gen Hosp Northern Mil Area, Dept Stomatol, 83 Wenhua Rd, Shenyang 110016, Peoples R China 4.Chinese Acad Sci, Translat Med R&D Ctr, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518057, Peoples R China 5.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China 6.Chinese Univ Hong Kong, Innovat Orthopaed Biomat & Drug Translat Res Lab, Li Ka Shing Inst Hlth, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Hui,Tang, Yulong,Zhang, Shuyuan,et al. Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology[J]. BIOACTIVE MATERIALS,2022,8:381-395.
APA	Liu, Hui.,Tang, Yulong.,Zhang, Shuyuan.,Liu, Huan.,Wang, Zijian.,...&Qin, Ling.(2022).Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology.BIOACTIVE MATERIALS,8,381-395.
MLA	Liu, Hui,et al."Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology".BIOACTIVE MATERIALS 8(2022):381-395.