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Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration
Chang, Peng1; Zhang, Wenchang2; Wu, Mi2; Zou, Rufei2; Song, Xiaoqiang4; Sun, Qian5; Gao, Junqing3; Zhao, Yan2; Liu, Yunhui1
Corresponding AuthorChang, Peng(cp17625@163.com) ; Gao, Junqing(gao-7950@163.com) ; Zhao, Yan(zhaoyan@jihualab.com) ; Liu, Yunhui(liuyh@sj-hospital.org)
2022-01-12
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Pages10
AbstractThe construction of intact functional skin is a challenging field in tissue engineering. Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough. Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity. Chitosan/gelatin non-woven fabric is used as the scaffold. MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting. A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA). Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering. It supports layered and 3D growth of MFUS. The degradation rate of chitosan, including filament diameter and density is evaluated in vivo. MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation. This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
Keywordchitosan gelatin minimal functional unit of skin (MFUS) tissue-engineered skin wound healing
Funding OrganizationShenyang Science and Technology Bureau ; Guangdong Climbing Peaks Program for High-level Hospital Development ; Science & Technology Department of Liaoning Province ; State Key Laboratory of Robotics, China ; Shengjing Hospital 345 Talent Project
DOI10.1002/mabi.202100419
Indexed BySCI
Language英语
Funding ProjectShenyang Science and Technology Bureau[19-109-4-02] ; Shenyang Science and Technology Bureau[21-172-9-15] ; Guangdong Climbing Peaks Program for High-level Hospital Development[202000240] ; Science & Technology Department of Liaoning Province[2021-KF-22-16] ; State Key Laboratory of Robotics, China[2021-KF-22-16] ; Shengjing Hospital 345 Talent Project
WOS Research AreaBiochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS IDWOS:000741940000001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/173734
Collection中国科学院金属研究所
Corresponding AuthorChang, Peng; Gao, Junqing; Zhao, Yan; Liu, Yunhui
Affiliation1.China Med Univ, Shengjing Hosp, Dept Plast & Reconstruct & Neurosurg Surg, Shenyang 110004, Peoples R China
2.Jihua Lab, Foshan 528000, Peoples R China
3.Foshan Hosp Tradit Chinese Med, Foshan 528000, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
5.Gen Hosp Northern Ctr Command, Expt Anim Ctr, Shenyang 110084, Peoples R China
Recommended Citation
GB/T 7714
Chang, Peng,Zhang, Wenchang,Wu, Mi,et al. Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration[J]. MACROMOLECULAR BIOSCIENCE,2022:10.
APA Chang, Peng.,Zhang, Wenchang.,Wu, Mi.,Zou, Rufei.,Song, Xiaoqiang.,...&Liu, Yunhui.(2022).Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.MACROMOLECULAR BIOSCIENCE,10.
MLA Chang, Peng,et al."Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration".MACROMOLECULAR BIOSCIENCE (2022):10.
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