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Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure
Kang, Kai1,2; Liu, Yunen3; Song, Xiaoqiang1,2; Xu, Lei1; Zhang, Wenchang4; Jiao, Yilai1; Zhao, Yan4
Corresponding AuthorZhao, Yan(zhaoyan@jihualab.com)
2022-05-13
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Pages10
AbstractBiomedical materials with effective hemostatic properties are in great demand in clinical and battlefield application for severe hemorrhage control. In this study, nearly amorphous chitin is obtained by treating alpha-chitin with superfine grinding, and the solubility of chitin in hexafluoro-2-propanol (HFIP) is significantly increased. Chitin and gelatin mixtures are prepared by adding different amount of gelatin to the 8 mg mL(-1) chitin solution. In the presence water (nonsolvent), the mixtures are gelled as HFIP is replaced by water, and chitin/gelatin composite sponges with directional pore structure are prepared by directional freeze drying of the hydrogel. The structure, porosity, liquid absorbing capacity, biodegradability, and hemostatic properties of the sponges with different ratios of gelatin are investigated. The results show that the sponge with the mass ratio of chitin/gelatin of 1:1 is potential hemostatic material with high absorbing capacity, hemocompatibility, and the best hemostatic performance. The in vivo study demonstrates that hemostatic time of the composite sponge (73 s) is much shorter than of that of gauze (193 s), chitin sponge (132 s) as well as gelatin sponge (116 s) in rat femoral artery injury model.
Keywordchitin directional pore gelatin hemostatic sponges
Funding OrganizationNational Natural Science Foundation of China
DOI10.1002/mabi.202200020
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U1608255]
WOS Research AreaBiochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS IDWOS:000794261400001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/173894
Collection中国科学院金属研究所
Corresponding AuthorZhao, Yan
Affiliation1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
3.Shenyang Med Coll, 146 Huanghe North St, Shenyang 110034, Peoples R China
4.Jihua Lab, 28 Isl Ring South Rd,Guicheng St, Foshan 528200, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Kang, Kai,Liu, Yunen,Song, Xiaoqiang,et al. Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure[J]. MACROMOLECULAR BIOSCIENCE,2022:10.
APA Kang, Kai.,Liu, Yunen.,Song, Xiaoqiang.,Xu, Lei.,Zhang, Wenchang.,...&Zhao, Yan.(2022).Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure.MACROMOLECULAR BIOSCIENCE,10.
MLA Kang, Kai,et al."Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure".MACROMOLECULAR BIOSCIENCE (2022):10.
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