| Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure | |
| Kang, Kai1,2; Liu, Yunen3; Song, Xiaoqiang1,2; Xu, Lei1; Zhang, Wenchang4; Jiao, Yilai1; Zhao, Yan4 | |
| Corresponding Author | Zhao, Yan(zhaoyan@jihualab.com) |
| 2022-05-13 | |
| Source Publication | MACROMOLECULAR BIOSCIENCE
 |
| ISSN | 1616-5187 |
| Pages | 10 |
| Abstract | Biomedical materials with effective hemostatic properties are in great demand in clinical and battlefield application for severe hemorrhage control. In this study, nearly amorphous chitin is obtained by treating alpha-chitin with superfine grinding, and the solubility of chitin in hexafluoro-2-propanol (HFIP) is significantly increased. Chitin and gelatin mixtures are prepared by adding different amount of gelatin to the 8 mg mL(-1) chitin solution. In the presence water (nonsolvent), the mixtures are gelled as HFIP is replaced by water, and chitin/gelatin composite sponges with directional pore structure are prepared by directional freeze drying of the hydrogel. The structure, porosity, liquid absorbing capacity, biodegradability, and hemostatic properties of the sponges with different ratios of gelatin are investigated. The results show that the sponge with the mass ratio of chitin/gelatin of 1:1 is potential hemostatic material with high absorbing capacity, hemocompatibility, and the best hemostatic performance. The in vivo study demonstrates that hemostatic time of the composite sponge (73 s) is much shorter than of that of gauze (193 s), chitin sponge (132 s) as well as gelatin sponge (116 s) in rat femoral artery injury model. |
| Keyword | chitin directional pore gelatin hemostatic sponges |
| Funding Organization | National Natural Science Foundation of China |
| DOI | 10.1002/mabi.202200020 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[U1608255] |
| WOS Research Area | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| WOS Subject | Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science |
| WOS ID | WOS:000794261400001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/173894 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhao, Yan |
| Affiliation | 1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Shenyang Med Coll, 146 Huanghe North St, Shenyang 110034, Peoples R China 4.Jihua Lab, 28 Isl Ring South Rd,Guicheng St, Foshan 528200, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Kang, Kai,Liu, Yunen,Song, Xiaoqiang,et al. Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure[J]. MACROMOLECULAR BIOSCIENCE,2022:10. |
| APA | Kang, Kai.,Liu, Yunen.,Song, Xiaoqiang.,Xu, Lei.,Zhang, Wenchang.,...&Zhao, Yan.(2022).Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure.MACROMOLECULAR BIOSCIENCE,10. |
| MLA | Kang, Kai,et al."Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure".MACROMOLECULAR BIOSCIENCE (2022):10. |
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