Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure

doi:10.1002/mabi.202200020

IMR OpenIR

	Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure
	Kang, Kai 1,2; Liu, Yunen 3; Song, Xiaoqiang 1,2; Xu, Lei 1; Zhang, Wenchang 4; Jiao, Yilai 1; Zhao, Yan 4
通讯作者	Zhao, Yan(zhaoyan@jihualab.com)
	2022-05-13
发表期刊	MACROMOLECULAR BIOSCIENCE
ISSN	1616-5187
页码	10
摘要	Biomedical materials with effective hemostatic properties are in great demand in clinical and battlefield application for severe hemorrhage control. In this study, nearly amorphous chitin is obtained by treating alpha-chitin with superfine grinding, and the solubility of chitin in hexafluoro-2-propanol (HFIP) is significantly increased. Chitin and gelatin mixtures are prepared by adding different amount of gelatin to the 8 mg mL(-1) chitin solution. In the presence water (nonsolvent), the mixtures are gelled as HFIP is replaced by water, and chitin/gelatin composite sponges with directional pore structure are prepared by directional freeze drying of the hydrogel. The structure, porosity, liquid absorbing capacity, biodegradability, and hemostatic properties of the sponges with different ratios of gelatin are investigated. The results show that the sponge with the mass ratio of chitin/gelatin of 1:1 is potential hemostatic material with high absorbing capacity, hemocompatibility, and the best hemostatic performance. The in vivo study demonstrates that hemostatic time of the composite sponge (73 s) is much shorter than of that of gauze (193 s), chitin sponge (132 s) as well as gelatin sponge (116 s) in rat femoral artery injury model.
关键词	chitin directional pore gelatin hemostatic sponges
资助者	National Natural Science Foundation of China
DOI	10.1002/mabi.202200020
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U1608255]
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:000794261400001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/173894
专题	中国科学院金属研究所
通讯作者	Zhao, Yan
作者单位	1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Shenyang Med Coll, 146 Huanghe North St, Shenyang 110034, Peoples R China 4.Jihua Lab, 28 Isl Ring South Rd,Guicheng St, Foshan 528200, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Kang, Kai,Liu, Yunen,Song, Xiaoqiang,et al. Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure[J]. MACROMOLECULAR BIOSCIENCE,2022:10.
APA	Kang, Kai.,Liu, Yunen.,Song, Xiaoqiang.,Xu, Lei.,Zhang, Wenchang.,...&Zhao, Yan.(2022).Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure.MACROMOLECULAR BIOSCIENCE,10.
MLA	Kang, Kai,et al."Hemostatic Performance of alpha-Chitin/Gelatin Composite Sponges with Directional Pore Structure".MACROMOLECULAR BIOSCIENCE (2022):10.