3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models

doi:10.1039/d2nr02176e

IMR OpenIR

	3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models
	Nie, Ran 1,2; Sun, Yue 1,2; Lv, Huixin 1,2; Lu, Ming 3,4; Huangfu, Huimin 1,2; Li, Yangyang 1,2; Zhang, Yidi 1,2; Wang, Dongyang 2; Wang, Lin 1,2; Zhou, Yanmin 1,2
通讯作者	Zhou, Yanmin(zhouym@jlu.edu.cn)
	2022-06-09
发表期刊	NANOSCALE
ISSN	2040-3364
卷号	14 期号:22 页码:8112-8129
摘要	The repair of infected bone defects with irregular shapes is still a challenge in clinical work. Infected bone defects are faced with several major concerns: the complex shapes of bone defects, intractable bacterial infection and insufficient osseointegration. To solve these problems, we developed a personalized MXene composite hydrogel scaffold GelMA/beta-TCP/sodium alginate (Sr2+)/MXene (Ti3C2) (GTAM) with photothermal antibacterial and osteogenic abilities by 3D printing. In vitro, GTAM scaffolds could kill both Gram-positive and Gram-negative bacteria by NIR irradiation due to the excellent photothermal effects of MXene. Furthermore, rat bone marrow mesenchymal stem cells were mixed into GTAM bioinks for 3D bioprinting. The cell-laden 3D printed GTAM scaffolds showed biocompatibility and bone formation ability depending on MXene, crosslinked Sr2+, and beta-TCP. In vivo, we implanted 3D printed GTAM scaffolds in S. aureus-infected mandible defects of rats with NIR irradiation. GTAM scaffolds could accelerate the healing of infection and bone regeneration, and play synergistic roles in antibacterial and osteogenic effects. This study not only provides a strategy for the precise osteogenesis of infected bone defects, but also broadens the biomedical applications of MXene photothermal materials.
资助者	National Natural Science Foundation of China ; Department of Finance of Jilin Province ; Department of Science and Technology of Jilin Province
DOI	10.1039/d2nr02176e
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82071152] ; Department of Finance of Jilin Province[JCSZ2020304-1] ; Department of Science and Technology of Jilin Province[20160101138JC]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000802331000001
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：66[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/174183
专题	中国科学院金属研究所
通讯作者	Zhou, Yanmin
作者单位	1.Jilin Univ, Hosp Stomatol, Dept Oral Implantol, Changchun 130021, Peoples R China 2.Jilin Univ, Hosp Stomatol, Jilin Prov Key Lab Tooth Dev & Bone Remodeling, Changchun 130021, Peoples R China 3.Jilin Normal Univ, Key Lab Funct Mat Phys & Chem, Joint Lab MXene Mat, Minist Educ, Changchun 130103, Jilin, Peoples R China 4.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Nie, Ran,Sun, Yue,Lv, Huixin,et al. 3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models[J]. NANOSCALE,2022,14(22):8112-8129.
APA	Nie, Ran.,Sun, Yue.,Lv, Huixin.,Lu, Ming.,Huangfu, Huimin.,...&Zhou, Yanmin.(2022).3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models.NANOSCALE,14(22),8112-8129.
MLA	Nie, Ran,et al."3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models".NANOSCALE 14.22(2022):8112-8129.